Impact of Protamine infusion Rate on Activated Clotting Time in Cardiac Surgery Patients undergoing Cardiopulmonary Bypass
Impact of Protamine Infusion Rate on Activated Clotting Time
Keywords:
protamine, cardiopulmonary bypass, open heart surgeryAbstract
Cardiac surgery is a complex surgery that use cardiopulmonary bypass machine for work as lung and heart for maintain oxygenation and circulation. Use of cardiopulmonary bypass machine increase risk clot and embolization due to abnormal surface contact between patient' blood volume and circuit system. Heparin must be given to maintain unclotted and heparinized system. After finished surgery the coagulation system that prolong by given heparin must be reverse by protamine for normal coagulation. This double blinded randomized controlled study compared two protamine dosing systems between protamine rate infusion 5 mg/min and total amount drip in 15 min. This study found that activated clotting time after reverse by two protamine systems were equivalence. Thus, a 15-minute infusion of protamine to counteract the action of heparin is equivalent to that of 5 mg/min
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