Treatment Outcomes and Factors Associated with Treatment Success among Adult Patients with Pulmonary Tuberculosis at Airborne Infection Clinic
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Abstract
Objective: To study treatment success rate and factors associated with treatment success among adult patients with pulmonary tuberculosis at Airborne Infection Clinic. Methods: This study was a retrospective study in patients with pulmonary tuberculosis aged 18 and over receiving treatment at Airborne Infection Clinic. The study collected the data on patient characteristics i.e. age, sex, weight, height, occupation and health insurance benefit, history of tuberculosis treatment and underlying disease, physical & laboratory examination, and treatment outcomes (efficacy and safety) from those receiving treatment during January 2018 to December 2021. Multiple logistics regression was employed to identify factors associated with treatment success. Results: The majority of 538 pulmonary tuberculosis patients were male (60.4%), infected by drug-susceptible tuberculosis (87.2%) and having no HIV co-infection (93.3%). Treatment success rate of adult patients with pulmonary tuberculosis at Airborne Infection Clinic was 82.9%. Factors associated with treatment success were age, weight, HIV infection and sputum AFB smear. Treatment success rate of patients who were under 60 years old was 2.11 times higher than those over 60 years old (95%CI: 1.26-3.56, P = 0.005). Success rate of those over 40 kg was 2.46 times higher than those with weight less than or equal to 40 kg (95%CI: 1.27-4.77,
P = 0.008). Rate of success of those without HIV co-infection was 5.84 times higher than those with HIV co-infection (95%CI: 2.62-13.05, P < 0.001). Treatment success rate of patients with sputum AFB smear negative was 2.06 times higher than those having sputum AFB smear 3+ (95%CI: 1.06-3.97, P = 0.032). Conclusion: Treatment success of adult patients with pulmonary tuberculosis at Airborne Infection Clinic was below the goal set by Ministry of Public Health. Factors associated with lower success rate of pulmonary tuberculosis treatment were aged 60 and over, weight
less than 40 kg, HIV infection and sputum AFB smear positive 3+.
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ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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