Incidence of Gastrointestinal Bleeding in Thai Patients with Acute Coronary Syndrome in Concomitant Use of Dual Antiplatelet Therapy and Proton Pump Inhibitors
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Abstract
Objective:To study the incidence of gastrointestinal bleeding in Thai patients with acute coronary heart syndrome receiving dual antiplatelet therapy (DAPT) in combination with acid proton pump inhibitors (PPIs), and to assess the appropriateness of PPI prescribing. Methods: This research was a descriptive study by retrospectively collecting the data from 738 patients with acute coronary heart disease treated with DAPT and PPIs at the Central Chest Institute during January 2016 - December 2017. The main outcome was gastrointestinal bleeding. Results: The incidence of gastrointestinal bleeding was 1.49 percent. Review of the appropriateness of the use of PPIs combined with DAPT found that 54.61 percent of patients needed no PPIs. Patients with indications of PPIs had an incidence of gastrointestinal bleeding of 2.1 percent while the incidence in those with no needs for PPIs only 1 percent. Conclusion: Although patients received DAPT with PPIs to prevent gastrointestinal adverse events, those at high risk and with indications of PPIs still had a twice rate of gastrointestinal bleeding than those with no indication of PPIs. Pharmacists should provide appropriate information on medication use, including advice on self-care for patients treated with DAPT to reduce the risk of adverse reactions in gastrointestinal system, especially gastrointestinal bleeding.
Article Details
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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