Prevalence and antibiotic use in hospitalized patients with a history of penicillin allergy
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Abstract
Objectives: To explore the prevalence of hospitalized patients with a history of penicillin allergy and the pattern of prescribed antibiotics in these patients. Methods: A cross-sectional study was conducted in the following three departments: surgery, internal medicine and orthopedics at Maharaj Nakorn Chiang Mai Hospital from January 1 to December 31, 2014 using electronic medical records as data source. Results: Overall, 339 hospitalized patients with a history of self-reported penicillin allergy were identified, given a prevalence of 1.2% among 28,025 patients (95% CI 1.1, 1.3). One hundred and ninety-four subjects were female (57.2%). Median age of the subjects was 61 years old (range: 52-74). There were 178 patients (52.5%) with age more than 60 years old. The most common reported drug allergy was natural penicillins (241 reports or 69.7%). The most frequently reported drug reaction type was skin reaction (293 reports or 84.7%). The five most common antibiotics prescribed to this group of patients were cephalosporins (20.6%), clindamycin (20.6%), fluoroquinolones (17.2%), carbapenems (10.0%), and vancomycin (6.8%). Conclusions: The prevalence of hospitalized patients with a history of penicillin allergy is quite low at Maharaj Nakorn Chiang Mai Hospital. Pattern of antibiotic prescription in this group of patients was similar to that reported in the previous studies. Documenting a detailed allergy history as well as consulting with allergists could increase the safe use of β-lactam antibiotics among this population and improve patient outcomes.
Article Details
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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