A Systematic Review and Meta-analysis on Efficacy of Derris scandens (Roxb.) Benth for Pain Reliever
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Abstract
Objective: To systematically review the literature and conduct meta-analysis on the efficacy of Derris scanden in pain reduction. At present, there were no systematic review and meta-analysis on D. scanden efficacy. Methods: Published articles were searched from electronic databases including Pubmed, CENTRAL, ScienceDirect, SciSearch and Thailis as well as hand search for unpublished studies. Studies with randomized controlled trial design in human, written in English or Thai, and conduced before 2015 were recruited. Results: Three papers met inclusion criteria with high quality of methodology with Jadad’s score ³3. The number of patients in the studies ranged from 70-178. All of the studies were conducted in Thailand and in patients with osteoarthritis and low back pain. Resulted showed no statistically significant difference of efficacy in pain reduction between D. scanden and NSAIDs (mean difference = 0.01; 95%CI=-0.13, 0.14). There were no statistically significant differences in laboratory examination. ADRs were not significantly different between two groups (RR= -0.84; 95%CI=0.63, 1.11). The most frequent reported ADRs in both groups were GI irritation and dizziness respectively. No serious ADRs were detected in these studies. Conclusion: This study suggests that therapeutic efficacy of D. scanden is not different from that of NSAIDs. This suggests that D. scandens can be used as an alternative pain killer.
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ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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