Quality of Dicloxacillin Sodium in the Forms of Dry Powder for Oral Suspension and Capsules Storied at the Storage Rooms of Subdistrict Health Promoting Hospitals at Tak Bai District, Narathiwat

Abstract

Objective: To determine the quality of dicloxacillin sodium in the forms of dry powder for liquid preparation and capsules in the actual conditions in the storage room of Subdistrict Health Promotion Hospitals in Tak Bai District, Narathiwat. Method: This study was action research by storing one brand of dry powder of dicloxacillin sodium and one brands of capsules in the same medication in one room with air conditioner and the other without air conditioner for a period of 8 months. The study sampled and analyzed medication according to the selected standard in the USP34 standards at 0, 4 and 8 months. The study also monitored temperature and humidity of the rooms in order to evaluate the effect of storage conditions on drug stability. The study then suggested the improvement of inventory management. Results: Quality of the drugs in both storage rooms remained throughout 8 months of study according to the selected standard assessment. At the same time, temperature and relative humidity of the storage room without air conditioning were higher than the conditions specified on drug label. It is assumed that having the appropriate primary packaging will prevent the degradation of the drug from the main factors, i.e., moisture. Conclusion: Data on the risk factors of drug instability both from the pharmaceuticals and the storage conditions are essential. In addition, the conditions specified on the label should be used as criteria to assess the risk and suggest risk reduction.