Changes in Serum Creatinine after Received Colistin
Changes in Serum Creatinine after Received Colistin
Keywords:
Serum creatinine, Colistin administration, Acute kidney injuryAbstract
Multidrug-resistant gram-negative bacteria is a major problem in nosocomial infections resulting in more use of colistin. Drug administration is either intravenous only, intravenously with nebulization, and nebulization alone. There is no clear serum creatinine monitoring, leading to poor outcomes in some patients. The purpose of this analytic study was to analyze the above three colistin dosage forms on acute renal injury (AKI) and factors associated with AKI. Retrospective data were collected from medical records of in-patient age 15 years and over who used colistin in Srisangworn Hospital, Sukhothai between January 1, 2018 and June 30, 2019, recorded serum creatinine follow-up 20 days. Quantitative results were presented by frequency, percentage, mean and standard deviation. Comparison of personal/clinical data between those with/without AKI using chi-square, Mann-Whitney U and independent t statistics. Factors associated with AKI were analyzed by univariate logistic regression and multiple logistic regression. Elderly population, males, intravenous monotherapy and intravenous combined with nebulization, long duration were significantly risk factors for AKI. This can be used for colistin prescribing guidelines, as well as for the surveillance and monitoring of AKI
References
Noopetch P, Suanrabbit C. Gram-negative resistance: mechanisms and clinical implement. In: Wanichanan C, Paitoonpong L, editors. Combat the resistance. Bangkok, Thailand: Print & More; 2018. p.141-370.
Mendes RE, Mendoza M, Banga Sigh KK, Castanheira M, Bell JM, Turnidge JD, et al. Regional resistance surveillance program results for 12 Asia-Pacific nations (2011).Antimicrob Agents Chemother 2013;57(11):5721-6.
Rice LB. Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones. Mayo Clin Proc 2012;87(2):198-208.
Rattanaamphawan P. Promoting and directing the proper use of antimicrobial drugs in hospital. In: Rattanaamphawan P, editor. Treatment of antimicrobial resistant gram-negative bacterial infections. Bangkok, Thailand: Siriraj Publishing House; 2018. p.143-72.
Thamlikitkul W. Colistin: an antimicrobial drug for the treatment of gram-negative infections. Siriraj Med Bull 2008;1(3):152-7. [cited 2018 Apr 5]. Available from: https://he02.tci-thaijo.org/index.php/simedbull/article/view/82129/65276
Sitaruno S, Sintimaleworakul W. Efficacy and safety of the practical use of colistin. Thai J Pharm Pract 2018;10(2):505-16.
Kritmethapak K. Acute kidney injury. In: Kritmethapak K, editor. Handbook of clinical nephrology. Khon Kaen, Thailand:Department of Internal Medicine, Khon Kaen University: 2019. p.1-126.
Colistimetate Sodium. In: In depth answers [database on the internet]. 2018 [cited 2018 Apr 5]. Available from: www.micromedex solutions.com
Kumanachai P. Principles of pharmacokinetics and pharmacokinetics in antimicrobial dosage adjustments. In: Rattanaamphawan P, editor. Treatment of antimicrobial resistant gram-negative bacterial infections. Bangkok, Thailand: Siriraj Publishing House; 2018. p.111- 21.
Nation RL, Garonzik SM, Thamlikitkul V, Giamarellos-Bourboulis EJ, Forrest A, Paterson DL, et al. Dosing guidance for intravenous colistin in critically-ill patients. Clin Infect Dis 2017;64(5):565-71.
Rattanaumpawan P, Lorsutthitham J, Ungprasert P, Angkasekwinai N, Thamlikitkul V. Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by gram-negative bacteria. J Antimicrob Chemother 2010;65(12):2645-9.
Kim YK, Lee JH, Lee HK, Chung BC, Yu SJ, Lee HY, et al. Efficacy of nebulized colistin-based therapy without concurrent intravenous colistin for ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii. J Thorac Dis 2017; 9(3):555-67.
Hamer DH. Treatment of nosocomial pneumonia and tracheobronchitis caused by multidrug-resistant Pseudomonas aeruginosa with aerosolized colistin. Am J Respir Crit Care Med 2000;162(1):328-30.
Athanassa ZE, Myrianthefs PM, Boutzouka EG, Tsakris A, Baltopoulos GJ. Monotherapy with inhaled colistin for the treatment of patients with ventilator-associated tracheobronchitis due to polymyxin-only-susceptible gram-negative bacteria. J Hosp Infect 2011;78(4):335-6.
Areewattanon W. Factors associated with acute kidney Injury in patients taking colistin at Nongkhai Hospital. Sakon Nakhon Hospital Med J 2021;24(3):46-56.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Buddhachinaraj Medical Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
