Clinical Significance of Random Urine Amylase in Acute Pancreatitis Diagnosis

Random Urine Amylase in Acute Pancreatitis Diagnosis

Abstract

Acute pancreatitis is a common surgical disease. Diagnosis  of acute pancreatitis prefers to use clinical presentation and biochemical marker. Serum amylase remains commonly  used as a biochemical marker for diagnosis of acute  pancreatitis, but its sensitivity is variable. However, when  using urinary amylase values collected 2 hours or 24 hours,  the sensitivity and specificity values were higher than  serum amylase values. But Buddhachinraj Phitsanulok  Hospital mostly uses random urine amylase, which has no  clear cut-off point value. The aim of this study was to assess  the amylase values in urine collected at any time to  assist in the diagnosis of acute pancreatitis by comparing it  with serum amylase. A retrospective study of the medical  records of patients with acute pancreatitis admitted to  Surgery Department during the year 2017-2021 were  conducted. It was found that the cut-off point of amylase in  the blood was greater than/equal to 240 U/L with the  examination price of 110 baht. The cut-off value of amylase  in the urine collected at any time was greater than/equal to720 U/L by the examination price of 108 baht. The  sensitivity of amylase values in the urine collected at any  time and in the blood were 92% and 72.4%, respectively.  The specificity of the amylase values in the urine collected at any time and in the blood were 97% and 93.9%,  respectively. When either one or both blood and urine amylase values collected at any time, it was found that the  sensitivity was statistically significantly increased to 97.2%. Therefore, urinary amylase values collected at any time can  be used to diagnose acute pancreatitis.