Factors Associated with Adverse Reactions after COVID-19 Vaccination in Phon District, Khon Kaen Province

Abstract

Introduction: Vaccination can control the epidemics and reduce the severity of COVID-19 efficiently. However, COVID-19 vaccination for population can have adverse reactions. Therefore, vaccinated people should be monitored after their vaccination in order to reduce possible adverse reactions. Objective: This research is to study the factors associated with of adverse reactions after COVID-19 vaccination in Phon District, Khon Kaen Province.      Methodology: This is a retrospective cohort study. Data were collected from database of medical records of 452 patients in Phon Hospital from 1 April 2021 to 31 September 2021. The monitoring was conducted after the patients got vaccinated 1 month through AEFI report, Hosxp program on Mor Prom Application. Generalized Linear Model (GLMs) was used for relationship analysis. Adjusted relative risk with 95 confidence interval (95%CI) was reported.        

Results: presented that patients younger than 40 years had 1.83 times more risk of adverse reactions when compared with patients aged 40 years and older (Adjusted RR=1.83; 95% CI=1.38-2.43). Patients who got the second  of the COVID-19 vaccine had 2.04 times more risk of adverse reactions when compared with those who got the first dose injection (Adjusted RR=2.04; 95%CI=1.60-2.60).Conclusion: Age 40 years and older and vaccine are significantly associated with the adverse reactions after COVID-19 vaccination. As a result, monitoring patients after vaccination should be carried on. In the meantime, the patients should be evaluated and assessed their risk before vaccination. Also, any symptoms should be reported after vaccination every 3, 7, and 30 days.