Survival Rate and Effect of Clinicopathological Characteristics on Survival of Stage IV Colon Cancer

Abstract

The objective of this study was to investigate survival rate and effect
of the clinicopathological characteristics on survival of stage IV colon cancer.
Method: the study design of this study was retrospective cohort study. All
interested variables were retrieved from medical records of patients with
stage IV colon cancer at Roi Et Hospital between January 1, 2010 to December
31, 2014. And all of the cases were followed up vital status until March 31,
2016. The statistical analyzed included descriptive statistics, KaplanMeier
survival curve, Logrank test and Cox proportional hazard model. Results:
Of 110 patients with stage IV colon cancer most of them were male 51.82%,
mean age 58.55 years (SD=14.29), marital status was couple 90.00%. The
total follow up time was 1, 528 personsmonths, median survival time was
12.00 months. At the end of study has 82 patients were death with mortality
rate was 5.36 per 100 personsmonths. The 6 months, 1, 2, 3 and 5 years
survival rate respectively were 69.01, 49.06, 24.14, 20.69 and 16.93.The data
analyzed revealed that descending colon (HR adj.: 3.32; 95% CI; 1.6515.93),
poorly differentiated (HR adj.: 2.21; 95% CI; 1.034.74), undifferentiated (HR
adj.: 3.61; 95% CI; 1.7415.15), distant metastases (HR adj.: 4.05; 95% CI;
1.7210.24), liver metastases (HR adj.: 4.98; 95% CI; 1.7214.45) and multiple
sites metastases (HR adj.: 9.03; 95% CI; 2.7429.80) were factors effected on
survival of stage IV colon cancer. Conclusion: poorly differentiated,
undifferentiated, cancer site at descending colon, liver metastasis, multiple
sites metastasis and distant metastases were factors effecting to stage IV
colon cancer.