Telepharmacy Services for Medication Review by Phone in Patients with Dementia Who Received Medication through Mail Delivery: A Descriptive Cross-Sectional Study
Main Article Content
Abstract
Objective: To determine the prevalence and types of drug-related problems (DRPs) associated with the treatment of dementia and the behavioral and psychological symptoms of dementia (BPSD) through medication review by phone in patients with dementia receiving their medications through postal mail. Methods: This study was cross-sectional descriptive research between November 2022 and January 2023. The subjects were dementia patients who obtained their dementia medication from Maharaj Nakorn Chiang Mai hospital through postal mail. The study identified DRPs through medication reviews and interviews with caregivers over the phone. The study classified DRPs according to the Pharmaceutical Care Network Europe (PCNE) version 5.01. Results: After screening 95 patients with dementia, a total of 55 participants were enrolled. The average age was 78.5±10.2 years. Patients were mostly females (64.4%) and having moderate dementia (38.2 %). BPSD was diagnosed in 83.6% of patients. A mean of 2.4±1.2 comorbidities was found among the subjects. Polypharmacy was identified in 81.8% of patients. Medication reviews identified 44 patients (80.0%) with 76 DRPs. The most common DRP was P4 drug use or drug administration problems (non-adherence) (31.6% of all identified DRPs), followed by P1 adverse drug reactions (26.3%) and of P6 other problems (19.7%) with the majority being P6.1 or dissatisfaction with therapy despite receiving appropriate medication. Conclusion: Medication reviews over telephone interviews could help identify DRPs in patients with dementia who received medication through postal mail. Pharmacists and health professionals should closely monitor medication compliance and adverse effects in this group of patients.
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
References
Thai Health Promotion Foundation. Developing a comprehensive care system for dementia patients [online]. 2019 [cited Feb 11, 2021]. Available from: www.thaihealth.or.th/Content/49850-%E0%B8% 9E%E0%B8%2.
Kaenork S. Dementia in the elderly [online]. 2005 [cited Jul 9, 2021]. Available from: www.dmh.go.th/ downloadportal/morbidity/dementia.pdf.
Neurological Institute of Thailand. Clinical practice guideline for dementia. Bangkok: Tanapress; 2021.
Rungruang K, Kanjanasilp J, Ploylearmsang C, Dud- sadeeprasert J. Pharmaceutical care in outpatients with dementia at Nakhon Ratchasima Rajanagarinda Psychiatric hospital. Isan Journal of Pharmaceutical Sciences. 2011; 7: 62-75.
Sooksa-art J, Thipraksa T, Hanrinth R, Kerdchantuk P, Suttiruksa S. Outcomes of pharmaceutical care in outpatients with Alzheimer’s disease: a pilot study. Thai Journal of Pharmacy Practice. 2018; 10: 129-41.
Xue Qin QN, Ming LC, Abd Wahab MS, Tan CS, Yuda A, Hermansyah A. Drug-related problems among older people with dementia: A systematic review. Res Social Adm Pharm 2023; 19: 873-81.
Lau ECY, Wojt I, Jeon YH, Hilmer SN, Tan ECK. Prevalence and risk factors for drug-related problems in people with dementia living in the community: a systematic review and meta-analysis. J Am Med Dir Assoc 2022; 23: 980-91.
Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, et al. Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future. Alzheimers Dement 2020; 16: 1571-81.
Pathak S, Haynes M, Qato DM, Urick BY. Tele- pharmacy and quality of medication use in rural areas, 2013-2019. Prev Chronic Dis. 2020; 17: E101. doi: 10.5888/pcd17.200012
Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986; 24: 67-74.
Sakthong P, Sonsa-Ardjit N, Sukarnjanaset P, Mun- pan W, Suksanga P. Development and psychometric testing of the medication taking behavior tool in Thai patients. Int J Clin Pharm 2016; 38: 438-45.
Thompson K, Kulkarni J, Sergejew AA. Reliability and validity of a new medication adherence rating scale (MARS) for the psychoses. Schizophr Res 2000; 42: 241-7.
Svarstad BL, Chewning BA, Sleath BL, Claesson C. The brief medication questionnaire: a tool for screening patient adherence and barriers to adherence. Patient Educ Couns 1999; 37: 113-24.
Risser J, Jacobson TA, Kripalani S. Development and psychometric evaluation of the self-efficacy for appropriate medication use scale (SEAMS) in low-literacy patients with chronic disease. J Nurs Meas 2007; 15: 203-19.
Jongwilaikasem K, Lerkiatbundit S. Development of the medication adherence scale for Thais (MAST). Thai Journal of Pharmacy Practice. 2021; 13: 17-30.
Chua SS, Kok LC, Yusof FA, Tang GH, Lee SW, Efendie B, et al. Pharmaceutical care issues identified by pharmacists in patients with diabetes, hypertension or hyperlipidaemia in primary care settings. BMC Health Serv Res 2012; 12: 388.
Hanrin R. Classification of drugs related problems. Thai Journal of Pharmacy Practice. 2009; 1: 84-96.
Cao Q, Tan CC, Xu W, Hu H, Cao XP, Dong Q, et al. The Prevalence of dementia: a systematic review and meta-analysis. J Alzheimers Dis 2020; 73: 1157-66.
Mekawichai P, Saetang S. Caregiver burden among Thai dementia patients' caregivers. Journal of the Psychiatric Association of Thailand. 2013; 58: 101-10.
Arts M, Petrykiv S, Fennema J, De Jonge L. Off-label prescriptions of quetiapine for sleep distur- bances. Eur Psychiatry 2017; 41: S749-S50.
Ruangritchankul S, Peel NM, Hanjani LS, Gray LC. Drug related problems in older adults living with dementia. PLoS One. 2020; 15: e0236830. doi: 10. 1371/journal.pone.0236830
Forgerini M, Lucchetta RC, Oliveira FM, Herdeiro MT, Capela MV, Mastroianni PdC. Impact of pharmacist intervention in patients with Alzheimer’s disease. Braz J Pharm Sci 2022; 15: 1-13.
Arlt S, Lindner R, Rösler A, von Renteln-Kruse W. Adherence to medication in patients with dementia: predictors and strategies for improvement. Drugs Aging 2008; 25:1033-47.
Gardette V, Lapeyre-Mestre M, Piau A, Gallini A, Cantet C, Montastruc JL, et al. A 2-year prospective cohort study of antidementia drug non-persistency in mild-to-moderate Alzheimer's disease in Europe: Predictors of discontinuation and switch in the ICTUS study. CNS Drugs 2014; 28: 157-70.
Poudel A, Nissen LM. Telepharmacy: a pharmacist's perspective on the clinical benefits and challenges.
Integr Pharm Res Pract 2016; 5: 75-82.
Hewitt H, Gafaranga J, McKinstry B. Comparison of face-to-face and telephone consultations in primary care: qualitative analysis. Br J Gen Pract 2010; 60: e201-12.
Allen K, Flewelling AJ, Munro L, Naylor H. Tele- phone versus in-person pharmacist-led medication reviews in home dialysis patients: evaluating quality of care and patient satisfaction. Pharmacy (Basel). 2022; 11: 1. doi: 10.3390/pharma cy11010001.