Evaluation of Cognitive Impairment in Cancer Patients with Solid Tumor after Adjuvant Chemotherapy at Sunpasitthiprasong Hospital, Ubon Ratchathani Province
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Abstract
Objective: To study the change of cognitive function in cancer patients with solid tumor after receiving adjuvant chemotherapy at Sunpasitthiprasong Hospital, Ubon Ratchathani Province.and to study factors related to the change of cognitive function in this group of patients. Methods: This research was a prospective observational study of cancer patients with solid tumor receiving adjuvant chemotherapy at the chemotherapy outpatient unit at Sunpasitthiprasong Hospital from September 28, 2021, to April 20, 2022. The FACT-Cog (Functional Assessment of Cancer Therapy - Cognitive Function) version 3 was used to assess cognitive impairment. The Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety and depression. There were three measurements in the study with the first one before the start of chemotherapy (T1), the second one at the half of the chemotherapy cycle (T2), and the third after chemotherapy (T3). Decrease in the FACT-Cog score more than 10.6 points from that at T1 indicated clinically important cognitive impairment. Results: Seventy-four patients were enrolled in the study. Incidences of cognitive impairment at T2 and T3 was 27.03% and 52.54%, respectively. Median scores of the FACT-Cog (interquartile ranges) significantly decreased from 120 (21) at T1 to 114 (32) and 110 (43) at T2 and T3, respectively (P<0.05). This indicated the increase in the severity of cognitive impairment after chemotherapy treatment. In addition, the study identified the relationship between age and the decreased cognitive function scores at T3 (P<0.05).Conclusion: Patients with solid tumors receiving adjuvant chemotherapy suffer from the increase of incidence and severity of cognitive impairment. Age is the factor related to the increase of the severity of cognitive impairment.
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ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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