General Knowledge for Pharmacists in Children Hematopoietic Stem Cell Transplantation
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Published:
Feb 10, 2019
Keywords:
pharmacists oncology in children hematopoietic stem cell transplantation preparative regimens
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Abstract
Hematopoietic stem cell transplantation (HSCT) is aimed to replace abnormal hematopoietic cells in bone marrow or increase the potential for complete cure of various serious diseases in children, such as hematologic malignancies, solid cancer, severe thalassemia, severe aplastic anemia, and primary immunodeficiencies. Prior to HSCT, the original stem cells in bone marrow must be destroyed by administration of high doses of chemotherapy with or without radiation or preparative regimens for 5-10 days, depending on the regimens. Hematopoietic stem cells (HSC) for transplantation may be collected from 3 sources including bone marrow, peripheral blood, or umbilical cord blood of the donor, and then are infused to patients after the completion of the preparative regimens. HSCT process may differ for each child depending on the type and severity of the disease, patient’s health status, type and source of HSCT, preparative regimens, and preventive medications for graft-versus-host disease (GVHD). Pharmacists have major responsibilities in checking the accuracy of prescription, preparing chemotherapy, and preventing complications from preparative regimens such as selection of proper medications for preventing chemotherapy-induced nausea and vomiting, oral mucositis, seizure caused by busulfan, and hemorrhagic cystitis from cyclophosphamide (prevented by using mesna), therapeutic drug monitoring of busulfan or various immunosuppressants to attain therapeutic levels. Moreover, pharmacists are helpful in preventing potential drug interactions to ensure patient safety.
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Research Articles
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
References
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10. Liewer S, Perkins J. Chapter 140: Hematopoietic stem cell transplantation. In: DiPiro JT editor, et al. Pharmacotherapy: A pathophysiologic approach. 10th ed. New York: McGraw-Hill Companies; 2017. p. 2305-21.
11. Motabi IH, DiPersio JF. Advances in stem cell mobilization. Blood Rev 2012;26:267-78.
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15. Gratwohl A, Baldomero H, Sureda A. Chapter 18: Indications for and current practice of allogeneic and autologous HSCT. In: Apperley J, Carreras E, Gluckman E, Masszi T, editors. ESH-EBMT hand book on haematopoietic stem cell transplantation 2012, 6th ed. Paris: European School of Haemato logy; 2012. p.306.
16. Majhail NS, Farnia SH, Carpenter PA, Champlin RE, Crawford S, Marks DI, et al. Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant 2015;21:1863-9.
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20. Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant 2009;15:1628-33.
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23. Lowsky R, Messner H. Chapter 77: Mechanisms and treatment of graft failure. In: Forman SJ, Negrin RS, Antin JH, Appelbaum FR, editors. Thomas' hematopoietic cell transplantation, 4th ed. UK: Wiley-Blackwell Publishing Chichester; 2016, p. 944-54.
24. Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J, et al. Guidelines for preventing infectious complications among hemato poietic cell transplant recipients: a global perspec tive. Preface Bone Marrow Transplant 2009;44: 1143-238.
25. Ardura MI. Overview of infections complicating pediatric hematopoietic cell transplantation. Infect Dis Clin N Am 2018;32:237-52.
26. Bride KL, Levy E, Wohlschlaeger A, Freedman JL. Chapter 17: Infectious complications and HSCT. In: Brown VL editor. Hematopoietic stem cell transplan tation for the pediatric hematologist/oncologist. USA: Springer International Publishing AG; 2018. p. 241-55.
27. Pasquini MC, Zhu X. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR summary slides [online]. 2012 [cited Apr 19, 2018]. Available format: www.cibmtr.org
28. National Comprehensive Cancer Network. Preven tion and treatment cancer related infection [online]. 2018. [cited 2018 Apr 21]. Available form: www.nc cn.org/professionals/physician_gls/pdf/infections.pdf
29. UpToDate. Busulfan: Pediatric drug information. [Online]. 2017 [cited Dec 18, 2017]. Available from:www.uptodate.com/contents/busulfan-pediatric -drug-information.
30. Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A et al. BCSH/BSBMT guideline: diag nosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation. Br J Haematol 2013;163:444-57.
31. Corbacioglu S, Cesaro S, Faraci M, Valteau-Couanet D, Gruhn B, Rovelli A et al. Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomized controlled trial. Lancet 2012;379:1301-09.
32. Tay J, Tinmouth A, Fergusson D, Huebsch L, Allan DS. Systematic review of controlled clinical trials on the use of ursodeoxycholic acid for the prevention of hepatic venoocclusive disease in hematopoietic stem cell transplantation. Biol Blood Marrow Trans plant 2007;13:206-17.
33. Ruutu T, Juvonen E, Remberger M, Remes K, Volin L, Mattsson J, et al. Improved survival with ursodeoxycholic acid prophylaxis in allogeneic stem cell transplantation: Long-term follow-up of a randomized study. Biol Blood Marrow Transplant 2014;20:135-8.
34. MIMS Thailand. Ursodeoxycholic acid [online]. 2018 [cited 20 Apr, 2018]. Available from: www. mims.com/thailand/drug/info/ursodeoxycholic%20aci d/?type=brief&mtype=generic
35. European medicines agency. Defibrotide: summary of product characteristics [online]. 2017 [cited Apr 17, 2018]. Available from: www.ema.europa.eu/doc s/en_GB/document_library/EPAR_-_Product_Inform ation/human/002393/WC500153150.pdf
36. Richardson PG, Riches ML, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM, et al. Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Blood 2016;127:1656-65.
37. Al Beihany A, Al Omar H, Sahovic E, Chaudhri N, Al Mohareb F, Al Sharif F, et al. Successful treatment of hepatic veno-occlusive disease after myeloablative allogeneic hematopoietic stem cell transplantation by early administration of a short course of methylprednisolone. Bone Marrow Trans plant 2008;41:287-91.
38. Myers KC, Lawrence J, Marsh RA, Davies SM, Jodele S. High-dose methylprednisolone for veno-occlusive disease of the liver in pediatric hemato poietic stem cell transplantation recipients. Biol Blood Marrow Transplant 2013;19:500-3.
39. Hastings CA, Torkildson JC, Agrawal AK. Chapter 24: Hematopoietic Stem Cell Transplantation. In: Hastings CA, Torkildson JC, Agrawal AK, editors. Handbook of pediatric hematology and oncology-children's hospital and research center Oakland. 2nd ed. UK: John Wiley & Sons; 2012. p.219
40. Hensley ML, Hagerty KL, Kewalramani T, Green DM, Meropol NJ, Wasserman TH, et al. American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants. J Clin Oncol 2009; 27:127-45.
41. Electronic medicines compendium. Mesna injection [online]. 2014 [cited Apr 17, 2018]. Available from: www.medicines.org.uk/emc/product/1838/smpc
42. Carless PA. WHO EML: final report-mesna (sodium 2-mercaptoethane sulfonate) [online]. 2008 [cited Apr 17, 2018]. Available from: www.who.int/selec tion_medicines/committees/expert/17/application/mesna_ inclusion.pdf
43. Patel P, Robinson PD, Thackray J, Flank J, Holdsworth MT, Gibson P, et al. Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: A focused update. Pediatr Blood Cancer 2017; 64: e 26542.
44. Sung L, Robinson P, Treister N, Baggott T, Gibson P, Tissing W, et al. Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. BMJ Support Palliat Care 2017;7:7-16.
45. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 2014;120:1453-61.
2. Sanpakit K. Overview in pediatric hematopoietic stem cell transplantation. J Med Assoc Thai 2005; 88: 1147-51.
3. Sanpakit K, Tabjareon S, Akaniroj S, Torsuwan N, Veerakul G. Analysis of hospital charges for hema topoietic stem cell transplantation in pediatric patients during admission at Siriraj hospital. J Hematol Transfus Med 2010;20:127-34.
4. National Cancer Institute. Childhood hematopoietic cell transplantation (PDQ®)-health professional version [online]. 2017 [cited Dec 18, 2017]. Availa ble from: www.cancer.gov/types/childhood-cancers /child-hct-hp-pdq
5. Sahdev I, Abdel-Azim H. Chapter 31: HematopoIe tic stem cell transplantation. In: Lanzkowsky P, editor. Manual of pediatric hematology and oncology. 6th ed. San Diego: Academic press; 2016. p. 577-604.
6. Phamorn W, Sanpakit K, Kupatawintu P, Aimyong N. The probability of finding an unrelated donor for stem cell waiting list patients at national blood center, Thai Red Cross Society. J Hematol Trans fus Med 2017;27:127-35.
7. Romphruk A. The importance of HLA antigen. J Hematol Transfus Med 2004;14:151-6.
8. Hirankarn N. Guideline for selecting donors for hematopoietic stem cell transplantation. J Hematol Transfus Med 2015;25:175-8.
9. Howard CA, Fernandez-Vina MA, Appelbaum FR, Confer DL, Devine SM, Horowitz MM, et al. Recommendations for donor human leukocyte antigen assessment and matching for allogeneic stem cell transplantation: consensus opinion of the Blood and Marrow Transplant Clinical Trials Network (BMTCTN). Biol Blood Marrow Transplant 2015;21:4-7.
10. Liewer S, Perkins J. Chapter 140: Hematopoietic stem cell transplantation. In: DiPiro JT editor, et al. Pharmacotherapy: A pathophysiologic approach. 10th ed. New York: McGraw-Hill Companies; 2017. p. 2305-21.
11. Motabi IH, DiPersio JF. Advances in stem cell mobilization. Blood Rev 2012;26:267-78.
12. Gluckman E. Chapter 6: Choice of the donor according to HLA typing and stem cell source. In: Apperley J, Carreras E, Gluckman E, Masszi T, editors. ESH-EBMT handbook on haematopoietic stem cell transplantation 2012, 6th ed. Paris: European school of haematology; 2012. p.93.
13. D’Souza A, Pasquini MC, Zhu X. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR summary slides [online]. 2016 [cited Dec 18, 2017]. Available from: www.cibmtr.org
14. Ljungman P, Bregni M, Brune M, Cornelissen J, de Witte T, Dini G, et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant 2010;45: 219-34.
15. Gratwohl A, Baldomero H, Sureda A. Chapter 18: Indications for and current practice of allogeneic and autologous HSCT. In: Apperley J, Carreras E, Gluckman E, Masszi T, editors. ESH-EBMT hand book on haematopoietic stem cell transplantation 2012, 6th ed. Paris: European School of Haemato logy; 2012. p.306.
16. Majhail NS, Farnia SH, Carpenter PA, Champlin RE, Crawford S, Marks DI, et al. Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant 2015;21:1863-9.
17. Gratwohl A, Carreras E. Chapter 8: Principles of conditioning. In: Apperley J, Carreras E, Gluckman E, Masszi T, editors. ESH-EBMT handbook on haematopoietic stem cell transplantation 2012, 6th ed. Paris: European school of haematology; 2012. p.123-36.
18. Green KGE, Rogosheske JR. Chapter 96: Hematopoietic cell transplantation. In: Alldredge BK et al., editor, Koda-Kimble and Young’s applied therapeutics: the clinical use of drugs. 10th ed. Philadelphia: Lippincott Williams &Wilkins; 2013. p. 2236-64.
19. Bensinger WI. Chapter 20: High-dose preparatory regimens. In: Forman SJ, Negrin RS, Antin JH, Appelbaum FR, editors. Thomas' hematopoietic cell transplantation, 4th ed. UK: Wiley-Blackwell Publish ing Chichester; 2016, p. 224.
20. Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant 2009;15:1628-33.
21. National Comprehensive Cancer Network. Chronic myelogenous leukemia [online]. 2018 [cited Apr 19, 2018]. Available form: www.nccn.org/professionnal s/physician_gls /pdf/cml .pdf
22. Carracedo C, Lawson AP. Chapter 98: HematopoI etic stem cell transplantation. In: Chisholm-Burns MA, Schwinghammer TL, Wells BG, Malone PM, Kolesar JM, Dipiro JT, editors. Pharmacotherapy principles & practice. 4th ed. New York: McGraw-Hill Companies; 2016. p.1445-59.
23. Lowsky R, Messner H. Chapter 77: Mechanisms and treatment of graft failure. In: Forman SJ, Negrin RS, Antin JH, Appelbaum FR, editors. Thomas' hematopoietic cell transplantation, 4th ed. UK: Wiley-Blackwell Publishing Chichester; 2016, p. 944-54.
24. Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J, et al. Guidelines for preventing infectious complications among hemato poietic cell transplant recipients: a global perspec tive. Preface Bone Marrow Transplant 2009;44: 1143-238.
25. Ardura MI. Overview of infections complicating pediatric hematopoietic cell transplantation. Infect Dis Clin N Am 2018;32:237-52.
26. Bride KL, Levy E, Wohlschlaeger A, Freedman JL. Chapter 17: Infectious complications and HSCT. In: Brown VL editor. Hematopoietic stem cell transplan tation for the pediatric hematologist/oncologist. USA: Springer International Publishing AG; 2018. p. 241-55.
27. Pasquini MC, Zhu X. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR summary slides [online]. 2012 [cited Apr 19, 2018]. Available format: www.cibmtr.org
28. National Comprehensive Cancer Network. Preven tion and treatment cancer related infection [online]. 2018. [cited 2018 Apr 21]. Available form: www.nc cn.org/professionals/physician_gls/pdf/infections.pdf
29. UpToDate. Busulfan: Pediatric drug information. [Online]. 2017 [cited Dec 18, 2017]. Available from:www.uptodate.com/contents/busulfan-pediatric -drug-information.
30. Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A et al. BCSH/BSBMT guideline: diag nosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation. Br J Haematol 2013;163:444-57.
31. Corbacioglu S, Cesaro S, Faraci M, Valteau-Couanet D, Gruhn B, Rovelli A et al. Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomized controlled trial. Lancet 2012;379:1301-09.
32. Tay J, Tinmouth A, Fergusson D, Huebsch L, Allan DS. Systematic review of controlled clinical trials on the use of ursodeoxycholic acid for the prevention of hepatic venoocclusive disease in hematopoietic stem cell transplantation. Biol Blood Marrow Trans plant 2007;13:206-17.
33. Ruutu T, Juvonen E, Remberger M, Remes K, Volin L, Mattsson J, et al. Improved survival with ursodeoxycholic acid prophylaxis in allogeneic stem cell transplantation: Long-term follow-up of a randomized study. Biol Blood Marrow Transplant 2014;20:135-8.
34. MIMS Thailand. Ursodeoxycholic acid [online]. 2018 [cited 20 Apr, 2018]. Available from: www. mims.com/thailand/drug/info/ursodeoxycholic%20aci d/?type=brief&mtype=generic
35. European medicines agency. Defibrotide: summary of product characteristics [online]. 2017 [cited Apr 17, 2018]. Available from: www.ema.europa.eu/doc s/en_GB/document_library/EPAR_-_Product_Inform ation/human/002393/WC500153150.pdf
36. Richardson PG, Riches ML, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM, et al. Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Blood 2016;127:1656-65.
37. Al Beihany A, Al Omar H, Sahovic E, Chaudhri N, Al Mohareb F, Al Sharif F, et al. Successful treatment of hepatic veno-occlusive disease after myeloablative allogeneic hematopoietic stem cell transplantation by early administration of a short course of methylprednisolone. Bone Marrow Trans plant 2008;41:287-91.
38. Myers KC, Lawrence J, Marsh RA, Davies SM, Jodele S. High-dose methylprednisolone for veno-occlusive disease of the liver in pediatric hemato poietic stem cell transplantation recipients. Biol Blood Marrow Transplant 2013;19:500-3.
39. Hastings CA, Torkildson JC, Agrawal AK. Chapter 24: Hematopoietic Stem Cell Transplantation. In: Hastings CA, Torkildson JC, Agrawal AK, editors. Handbook of pediatric hematology and oncology-children's hospital and research center Oakland. 2nd ed. UK: John Wiley & Sons; 2012. p.219
40. Hensley ML, Hagerty KL, Kewalramani T, Green DM, Meropol NJ, Wasserman TH, et al. American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants. J Clin Oncol 2009; 27:127-45.
41. Electronic medicines compendium. Mesna injection [online]. 2014 [cited Apr 17, 2018]. Available from: www.medicines.org.uk/emc/product/1838/smpc
42. Carless PA. WHO EML: final report-mesna (sodium 2-mercaptoethane sulfonate) [online]. 2008 [cited Apr 17, 2018]. Available from: www.who.int/selec tion_medicines/committees/expert/17/application/mesna_ inclusion.pdf
43. Patel P, Robinson PD, Thackray J, Flank J, Holdsworth MT, Gibson P, et al. Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: A focused update. Pediatr Blood Cancer 2017; 64: e 26542.
44. Sung L, Robinson P, Treister N, Baggott T, Gibson P, Tissing W, et al. Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. BMJ Support Palliat Care 2017;7:7-16.
45. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 2014;120:1453-61.
