Impact of Ontogeny on Pharmacokinetics and Pharmacodynamics in Pediatric Patients
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Abstract
Pediatric patients are different from adults because, at their age, biochemical and physiological functions of organ systems have not yet fully developed or functioned compare to adults. This affects age- pharmacokinetic and pharmacodynamic properties of drugs. Drug absorption is different in children with different ages. The major factors are differences in gastrointestinal pH and gastric emptying. For drug distribution, neonates have low serum protein concentration and high body water composition; therefore, their volume of distribution of many drugs is different from that of children in different ages. Hepatic metabolism and renal clearance are often immature at birth, but develop with advanced age, leading to the increase of drug clearance and reduction of half-life. There are limited data on the impact of ontogeny on pharmacodynamics, the effects may depend upon drugs.
Article Details
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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