A Systematic Review and Meta-analysis on Efficacy of Phytosterol for Lipid lowering in Patients Treated with HMG CoA Reductase Inhibitors
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Abstract
Objective: The previous studies found that phytosterol may improve lipid profile in patients treated with HMG CoA reductase inhibitors. However the results from clinical trials of phytosterol have been continuously inconsistent. The objective of this study was to systematically review literature and conduct the meta-analysis of the efficacy of phytosterol for controlling blood lipid levels. Methods: The researchers retrieved articles via electronic databases such as PubMed, CENTRAL, SCI=enceDirect, SciSearch and ThaiLis. Randomized controlled trials (RCT) in human reported in English or Thai and published before or within 2015 were used in data analysis. Results: The quality of 11 included studies was assessed according to the criteria of Jadad et al. The quality of most of the included studies was high with the score between 2 and 5. The number of participants in the studies ranged from 8 to 192. The study found that plant stanol could statistically significant reduce the level of low density lipoprotein (LDL) (mean difference (MD)= -0.45, 95% CI= -0.53,-0.37, p<0.001) and total cholesterol (TC) (MD= –0.33, 95% CI= -0.45, 0.21, p<0.001). However, plant stanol showed no effects on the other blood lipid levels (triglyceride; TG and high density lipoprotein; HDL). Plant sterol was not able to reduce any types of blood lipid levels. The study found no severe adverse effects from the use of phytosterol. Conclusion: The study supports that plant stanol, the product derived from phytosterol, reduces LDL and TC levels. However, there is a need for conducting RCT to confirm its effects on the other types of lipids.
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ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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