Effect of Folic acid on Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes
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Abstract
Objective: To determine the effects of folic acid on glycosylated hemoglobin levels (HbA1C) in type 2 diabetic patients. Method: The study was a double blind randomized controlled trial in type 2 diabetic patients with HbA1C between 7-10% and receiving metformin at least 1500 mg /day at Dok Kham Tai Hospital, Phayao province. The researchers randomly allocated patients into 2 groups i.e., 80 patients in study group receiving folic acid 5mg/day and 78 patients in control group receiving placebo for 3 months. The study compared mean HbA1C and fasting blood glucose (FBG) between and within groups using multilevel mixed-effects linear regression. Results: Mean HbA1C levels in the folic acid group at month 0 and month 3 were 8.20 ± 0.71% and 7.85 ± 0.82%, respectively, with a decrease of 0.23±0.89% (P=0.005). HbA1C levels in the placebo group at month 0 and month 3 were 8.13 ± 0.76% and 8.00 ±1.07 %, respectively, with a decrease of 0.119 ± 0.98 % (P=0.329). However, at the end of the study (month 3), mean HbA1C and the decrease in HbA1c levels between the folic acid group and the placebo group were not significantly different (P=0.593 and 0.466, respectively). There were no differences between the folic acid group and the placebo groups in FBG and FBG change. Conclusion: The use of folic acid 5 mg/day for 3 months in type 2 diabetic patients receiving metformin did not reduce FBG and HbA1C levels.
Article Details
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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