Effects of Education by Pharmacists Supplemented with Pictograms on the Use of Medications in Diabetic Patients
Main Article Content
Abstract
Objective: To evaluate the impact of education by pharmacists supplemented with pictograms of instruction for drug use on clinical outcomes, adherence to medications and knowledge in diabetes patients. Methods: The study design was a randomized controlled trial. Subjects were 145 type 2 diabetes patients attending two primary care units in Trang province. The patients were randomly allocated to the study group (n=72) and the control group (n=73). The study group received knowledge about diabetes and pictograms of instruction on drug use from a pharmacist every 8–13 weeks for a total of 4 times. The control group received usual care. The study period was approximately 10 months. Results: At the end of the study, the study group had significantly lower glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) levels than the control group (HbA1c=7.88±1.29% vs 8.55 ±1.32% respectively; P=0.002 and FPG=133.81±25.42 mg/dl vs 149.71±26.11 mg/dl respectively; P<0.001). In the study group, blood pressure levels at the end of the study were significantly lower than those at the beginning of the study (P<0.05), but they were not different from those in the control group (P>0.05). Lipid profiles between both groups were not different (P>0.05). Medication adherence scores and diabetes knowledge scores in the study group were significantly higher than those in the control group (medication adherence scores from pill count=90.78±4.92 vs 88.85±5.91 respectively (full score=100); P=0.034 and diabetes knowledge scores=12.15±1.12 vs 10.26±1.85 respectively (full score=13); P<0.001). Conclusion: Patient education by pharmacists supplemented with pictograms of instruction on drug use improved glycemic control, medication adherence and diabetes knowledge in patients with diabetes.
Article Details
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
References
2. Diabetes Association of Thailand. Diabetes clinical practice guideline 2011. Bangkok: Srimuang Publishers; 2011.
3. Bureau of Non Communicable Diseases, Ministry of Public Health. Annual report 2015. Bangkok: The War Veterans Organization of Thailand; 2016.
4. Trang Provincial Health Office. The top ten causes of outpatient diseases in Trang [online]. 2016 [cited October 15, 2016]. Available from: trg.hdc. moph.go.th/hdc/reports.
5. Schectman JM, Nadkarni MM, Voss JD. The association between diabetes metabolic control and drug adherence in an Indigent population. Diabetes Care 2002; 25: 1015-21.
6. Krapek K, King K, Warren SS, George KG, Caputo DA, Mihelich K, et al. Medication adherence and associated hemoglobin A1c in type 2 diabetes. Ann Pharmacother 2004; 38: 1357-62.
7. Suppapitiporn S, Chindavijak B, Onsanit S. Effect of diabetes drug counseling by pharmacist, diabetic disease booklet and special medication containers on glycemic control of type 2 diabetes mellitus: a randomized controlled trial. J Med Assoc Thai 2005; 88 (Suppl. 4): S134-41.
8. Omran D, Guirguis LM, Simpson SH. Systematic review of pharmacist interventions to improve adherence to oral antidiabetic medications in people with type 2 diabetes. Can J Diabetes 2012; 36: 292-9.
9. Vervloet M, Linn AJ, van Weert JC, de Bakker DH, Bouvy ML, van Dijk L. The effectiveness of interventions using electronic reminders to improve adherence to chronic medication: a systematic review. J Am Med Inform Assoc 2012; 19: 696-704.
10. Walker EA, Shmukler C, Ullman R, Blanco E, Scollan-Koliopoulus M, Cohen HW. Results of a successful telephonic intervention to improve diabetes control in urban adults. Diabetes Care 2011; 34: 2-7.
11. Fenerty SD, West C, Davis SA, Kaplan SG, Feldman SR. The effect of reminder systems on patients’ adherence to treatment. Patient Prefer Adherence 2012; 6: 127-35.
12. Bosworth HB. How can innovative uses of technology be harnessed to improve medication adherence. Expert Rev Pharmacoecon Outcomes Res 2012; 12: 133-5.
13. National Statistic Office, Thailand. Survey of using technology information and communi- cation in household [online]. 2013 [cited April 9, 2017]. Available from: service.nso.go.th/nso/nso publish/themes/files/icthh56.pdf.
14. Atreja A, Bellam N, Levy SR. Strategies to enhance patient adherence: making it simple. Med GenMed 2005; 7: 4.
15. George J, Elliott R, Stewart DC. A systematic review of interventions to improve medication taking in elderly patients prescribed multiple medications. Drugs Aging 2008; 25: 307-24.
16. Houts PS, Doak CC, Doak LG, Loscalzo MJ. The role of pictures in improving health communica- tion: a review of research on attention, compre- hension, recall and adherence. Patient Educ Couns 2006; 61: 173-90.
17. Kripalani S, Robertson R, Love-Ghaffari MH, Henderson LE, Praska J, Strawder A, et al. Development of an illustrated medication schedule as a low-literacy patient education tool. Patient Educ Couns 2007; 66: 368-77.
18. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol. JAMA 2006; 296: 2563-71.
19. Chundee U. Impact of self-medicated sample care for elderly diabetic outpatients at Warinchumrab hospital [master thesis]. Ubon Rajathanee: Ubon Rajathanee University; 2008.
20. Suvasuna P. Effects of pre-packaged unit dose examples on the medication compliance of hypertensive outpatients at Sikhoraphum Hospital, Surin Province [master thesis]. Ubon Rajathanee: Ubon Rajathanee University; 2008.
21. Angsuwattanakul B, Lerkiatbundit S. Development of pictograms for illiterate patients part 1: instructions on how to take tablets. Thai J Pharm Pract 2014; 6: 41-60.
22. Morisky DE, Ang A, Krousel-Wood M, Ward H. Predictive validity of a medication adherence mea- sure for hypertension control. J Clin Hypertens 2008; 10: 348-54.
23. Krousel-Wood MA, Islam T, Webber LS, Re RS, Morisky DE, Muntner P. New medication adherence scale versus pharmacy fill rates in seniors with hypertension. Am J
Manage Care 2009; 15: 59-66.
24. Morisky DE, DiMatteo MR. Improving the measure- ment of self-reported medication nonadherence: final response. J Clin Epidemio 2011; 64: 258-63.
25.Sinchai K. Effects of pharmacist-managed diabetes refilling clinic at Trang Hospital [master thesis]. Songkhla: Prince of Songkla University; 2004.
26. American Diabetes Association. Standards of medical care in diabetes-2017. Diabetes Care 2017; 40(Suppl. 1): S1- S135.
27. Farsaei S, Sabzghabaee AM, Zargarzadeh AH, Amini M. Effect of pharmacist-led patient education on glycemic control of type 2 diabetics: a randomized controlled trial. J Res Med Sci 2011; 16: 43-9.
28. Vik SA, Hogan DB, Patten SB, Johnson JA, Romonko-Slack L, Maxwell CJ. Medication nonad- herence and subsequent risk of hospitalization and mortality among older adults. Drugs Aging 2006; 23: 345-56
29. Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet 2016; 387: 435-43.
30. Nelson RH. Hyperlipidemia as a risk factor for cardiovascular disease. Prim Care 2013; 40: 195-211.
31. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA 2006; 296: 2563-71.
32. Zedler BK, Kakad P, Colilla S, Murrelle L, Shah NR. Does packaging with a calendar feature improve adherence to self-administered medica- tion for long-term use? A systematic review. Clin Ther 2011; 33: 62-73.
33. Asche C, LaFleur J, Conner C. A review of diabetes treatment adherence and the association with clinical and economic outcomes. Clin Ther 2011; 33: 74-109.
34. Sadakorn S, Saengcharoen W, Wongpoowarak P, Lerkiatbundit S. Clinical impact of pharmacist counseling on type 2 diabetes patients. Isan J Pharm Sci 2014; 9: 116-21.
35. McPherson ML, Smith SW, Powers A, Zuckerman IH. Association between diabetes patients’ know- ledge about medications and their blood glucose control. Res Social Adm Pharm 2008; 4: 37-45.