Efficacy of Non-Surgical Periodontal Treatment in Disease Activity of Rheumatoid Arthritis
Non-Surgical Periodontal Treatment and Rheumatoid Arthritis
Keywords:
periodontitis, rheumatoid arthritis, non-surgical periodontal treatmentAbstract
Rheumatoid arthritis (RA) and periodontitis (PD) are common chronic inflammatory diseases. Previous studies have shown the beneficial effect of periodontal treatment on reducing RA disease activity. Periodontal diseases are not only a threat to dentition but may also be a threat to general health. This randomized, controlled trial aimed to investigate the effect of non-surgical periodontal treatment on the severity of RA. Fifty patients diagnosed moderate RA were allocated to immediate (treatment group) or delayed (control group) non-surgical periodontal treatment (full mouth scaling, root planning and oral hygiene instruction). RA measurement and periodontal indices were recorded at baseline and 8 weeks for each participant. Results: The number of swollen joints, the number of tender joints, the level of pain, inflammatory marker; CRP, ESR, and severity of rheumatoid arthritis using DAS28 ESR and DAS28 CRP were significantly reduced in the treatment group. In the treatment group, the periodontal disease index improved in all indicators. This was different from that in the control group, which did not improve. In conclusion, non-surgical periodontal treatment reduces disease activity of rheumatoid arthritis
References
Khitdee C, Pochanukul N, Hasadisevee P, Yaebut N, Gururatana O, Agrasuta V, et al. Report of the 9th National Oral Health Survey, Thailand 2023. Nonthaburi, Thailand: Bureau of Dental Health, Department of Health, Ministry of Public Health; 2024.
Bonagura VR, Artandi SE, Davidson A, Randen I, Agostino N, Thompson K, et al. Mapping studies reveal unique epitopes on IgG recognized by rheumatoid arthritis-derived monoclonal rheumatoid factors. J Immunol 1993;151(7):3840-52.
Mirrielees J, Crofford LJ, Lin Y, Kryscio RJ, Dawson DR 3rd, Ebersole JL, et al. Rheumatoid arthritis and salivary biomarkers of periodontal disease. J Clin Periodontol 2010;37(12):1068-74.
Trombone AP, Claudino M, Colavite P, de Assis GF, Avila-Campos MJ, Silva JS, et al. Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences. Genes Immun 2010;11(6):479-89.
Chanal IC, Susanto A, Komara I. Association between severity of periodontitis and rheumatoid arthritis. J Syiah Kuala Dent Soc 2021;6(2):113-21.
Marotte H, Farge P, Gaudib P, Alexamdre C, Mougin B, Miossec P. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. Ann Rheum Dis 2005;65:905-9. Doi:
1136/ard.2005.036913
Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol 2007;13(3):134-7.
Pinho MN, Oliveira RD, Novaes AB. Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment. Braz Dent J 2009;20(5):355-64.
Okada M, Kobayashi T, Ito S, Yokoyama T, Abe A, Murasawa A, et al. Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis: randomized controlled trial. J Periodontol 2013;84(12):1774-84.
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31(3):315-24.
Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and peri-implant diseases and conditions: Introduction and key changes from the 1999 classification. J Clin Periodontol 2018;45(Suppl 20):S1-8.
Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Berglundh T, et al. Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline. J Clin Periodontol 2020;47(Suppl 22):4-60.
Segelnick SL, Weinberg MA. Reevaluation of initial therapy: when is the appropriate time? J Periodontol 2006;77(9):1598-601.
Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J, et al. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis 2009;68(6):954-60.
Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Clin Periodontol 2018;45(Suppl 20):S149-61.
O'Leary TJ, Drake RB, Naylor JE. The plaque control record. J Periodontol 1972;43(1):38. https://doi.org/10.1902/jop.1972.43.1.38
Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25(4):229-35.
Ngamjarus C, Chongsuvivatwong V, McNeil E. n4Studies: sample size calculation for an epidemiological study on a smart device. Siriraj Med J 2016;68(3):160-70.
Winkler P, Dannewitz B, Nickles K, Petsos H, Eickholz P. Assessment of periodontitis grade in epidemiological studies using interdental attachment loss instead of radiographic bone loss. J Clin Periodontol 2022;49(9):854-61.
Demmer RT, Molitor JA, Jacobs DR Jr, Michalowicz BS. Periodontal disease, tooth loss and incident rheumatoid arthritis: Results from the First National Health and Nutrition Examination Survey and its epidemiological follow-up study. J Clin Periodontol 2011;38(11):998-1006.
Pandya R, Shah M, Raval Y. Effect of non-surgical periodontal therapy on the severity of rheumatoid arthritis: A clinical and hematological study. Open J Stomatol 2020;10(1):1-9.
Nguyen VB, Nguyen TT, Huynh NC, Nguyen KD, Le TA, Hoang HT. Effects of non-surgical periodontal treatment in rheumatoid arthritis patients: A randomized clinical trial. Dent Med Probl 2021;58(1):97-105.
Sheng X, Ye X, Yuan H, Zheng C, Zheng T, Chen Q, et al. Assessing the efficacy of nonsurgical periodontal treatment in rheumatoid arthritis: An umbrella review. Quintessence Int 2025;56(4):260-72.
Monsarrat P, Gradoa GF, Constantine A, Willmann C, Nabet C, Sixou M, et al. The effect of periodontal treatment on patients with rheumatoid arthritis: The ESPERA randomized controlled trial. Joint Bone Spine 2019;86(5):600-9.
Saadeh C. The erythrocyte sedimentation rate: Old and new clinical applications. South Med J 1998;91(3):220-5.
Rovel A, L'Huillier JF, Vigneron C. Mechanisms of erythrocyte sedimentation. Biomedicine 1978;28(5):248-55.
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