Effectiveness of Topical Clotrimazole Cream versus Tincture Merthiolate in the Treatment of Otomycosis: A Randomized Controlled Trial

Effectiveness of the Treatment of Otomycosis

Abstract

Otomycosis is a common clinical problem in tropical regions. This prospective randomized controlled trial evaluated 61 patients with otomycosis to compare the effectiveness of topical clotrimazole cream and Tincture Merthiolate at Buddhachinaraj Phitsanulok Hospital. Patients were randomly assigned to receive either a single application of clotrimazole cream administered by a physician or Tincture Merthiolate, which they self-administered twice daily for 7 days. Follow-up was conducted on days 7 and 14. The study results showed no significant differences in baseline demographics, and initial mean pain scores were similar (mean difference = 0.12, 95% CI: - 1.49 to 1.72). Both groups showed significant improvement after 7 and 14 days of treatment, with over 90% of patients showing no fungal infection in the ear after 14 days. No significant differences were found between groups in most outcomes. However, in the Tincture Merthiolate group, aural fullness and tinnitus improved more quickly within the first 7 days. Complications were low, and most patients were highly satisfied. In conclusion, clotrimazole cream and Tincture Merthiolate are equally effective in treating ear fungal infections within 14 days, with Tincture Merthiolate potentially providing faster relief in the early stages. The choice of medication depends on convenience and availability