Important Clinical Characteristics in Predicting Abnormal Lymphadenopathy in Children
Abnormal Lymphadenopathy in Children
Keywords:
lymphadenopathy, children, lymph node biopsy, malignantAbstract
Lymphadenopathy in children, particularly in those palpable in normal regions, is a common finding. However, abnormal lymphadenopathy and malignancy occur less frequently and often exhibit distinctive clinical characteristics. This diagnostic prediction research aimed to identify the clinical features predictive of abnormal lymphadenopathy in a pediatric population by employing a diagnostic prediction approach. Clinical data gathered through retrospective cross-sectional analysis of medical records were obtained from children under 15 years of age who underwent lymph node biopsy at the Buddhachinaraj Phitsanulok Hospital between January 2012 and December 2022. Univariate risk ratio regression and multinomial logistic regression were utilized for individual and multiple predictors, respectively. Among 188 children who underwent excision, 70 (37.2%) exhibited benign abnormal lymphadenopathy and 27 (14.4%) had malignant conditions. Predictors for benign abnormal lymphadenopathy included localized lymphadenopathy, rubbery and fixed palpable lymph nodes. Predictors for malignancy included lymph node size larger than 1.5 centimeter, generalized lymphadenopathy, anemia, fatigue, and fixed palpable lymph nodes. Utilizing these clinical features can guide appropriate treatment and delivery for lymph node biopsy
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