Effectiveness of Intra-articularInjection of Tranexamic Acid 250 milligram versus 500 milligram in Reducing Blood Loss after Total Knee Arthroplasty
Effectiveness of Intra-articular Injection of Tranexamic Acid
Keywords:
total knee arthroplasty, intra-articular injection, tranexamic acid, blood loss, blood transfusionAbstract
Total knee arthroplasty (TKA) has become the gold standard to manage the pain and disability associated with knee posteoarthritis after patients fail nonoperative treatments. However, significant amount of blood loss may increase the frequency of allogeneic blood transfusion rates. fortunately, allogeneic blood transfusions have associated risks including postoperative infection, fluid overload, increased length of hospital stay, and increased mortality. This randomized controlled study compared effectiveness of intra-articular injection of tranexamic acid 250 milligram versus 500 milligram in reducing blood loss and blood transfusion after TKA of primary knee osteoarthritis patients at Sukhothai hospital from July, 2018-May, 2019. Of the 60 patients, the amount of blood volume in the Redivac drain at 24 hours, 48 hours and blood transfusion were significantly lower in 500 milligram intra-articular injection of tranexamic acid group without serious complications, such as hematoma, deep vein thrombosis, pulmonary embolism and prosthetic joint infection. In conclusion, 500 milligram intra-articular injection of tranexamic acid is an effective and safe method.
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