Characteristics and Outcomes of Cryptococcal Meninigitis among HIV and Non-HIV Infected Patients
Cryptococcal Meninigitis among HIV and Non-HIV Patients
Keywords:
cryptococcal meninigitis, HIV infected patients, non-HIV infected patients, risk factors, characteristicsAbstract
Cryptococcal meningitis from environment fungi in HIV infected and non-HIV infected patients has high rates of mortality and disability. The objective of this comparative analytical study was to assess the risk factors for cryptococcal meningitis among HIV infected and non-HIV infected individuals. Sick who came to be treated in Buddhachinaraj Phitsanulok Hospital both former and new patients during the year 2010-2020, 629 cases, divided into HIV infected and non-HIV infected groups. Calculate the sample size and randomize it systematically. There were 164 participants who met the diagnostic criteria. Risk factors for cryptococcal meningitis in non-HIV infected patients were mean age, diabetes, high blood pressure, and alcoholic liver disease, or history of severe alcohol consumption (p = 0.032, 0.002, 0.036, < 0.001, respectively), normal brain computed tomography and mean lymphocyte counts in cerebrospinal fluid (p < 0.001, < 0.001, respectively). Risk factors for cryptococcal meninigitis in HIV infected patients were positive Indian ink in CSF, positive culture for cryptococcus of CSF (p = 0.001, < 0.001, respectively) and there was 2.44 times greater chance that the cerebrospinal fluid test result found protein greater than or equal to 40 mg/dL more than in non-HIV infected patients (95% CI 1.99-2.99). Therefore, caregivers of patients with cryptococcal meningitis should be aware for these factors.
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