Effects of Antimicrobial Control Program on Appropriate Use of Antibiotics
Appropriate Use of Antibiotics
Keywords:
antimicrobial control program, appropriate antibiotic use, pharmacistAbstract
The problem of antimicrobial-resistant is a problem for health systems around the world. The purpose of this quasi-experimental study was to compare the appropriateness of drug use and consumption of piperacillin/tazobactam and meropenem pre- and post-intervention of antimicrobial control program. The study was conducted in patients who used these drugs in the pre-program period (September1, 2019 to February 28, 2020) and after the program period (September 1, 2020 to February 28, 2020). The program comprised educational approaches and introduction of DUE guidelines through intervention made by pharmacists and informed the doctor if an inappropriate prescription was found. Results show that 1,851 and 1,994 patients received piperacillin/tazobactam and meropenem in pre- and post-program respectively. The percentage of appropriate drug use during pre- and post-program were 96.1 % and 90.1 % respectively, (p < 0.001). Pharmacists detected 73 cases (3.9 %) and 198 cases (9.9 %) of inappropriate use of antibiotics during the two periods. The doctors changed their prescriptions after 47 interventions made by pharmacists (64.4 %) and 108 from 198 cases (54.5 %) in the two periods, respectively. After doctors used program, they adjusted the antimicrobial doses by 44.9 %. In term of Defined Daily Dose/1,000 inhabitants, showed consumption of piperacillin/tazobactam was significantly decreased, while meropenem consumption was statistically increased. In conclusion, effects of Antimicrobial Control Use Program with pharmacist participation can increase the appropriate use of antimicrobial especially on inappropriate dosage, but not on overall antibiotic consumption.
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