Factors Associated with Failure in Treatment of HIV Infected Pediatric Patients with Antiviral Drugs
Keywords:
factors, failure in treatment, HIV infected pediatric patients, antiviral drugsAbstract
Failure in treatment of HIV infected pediatric patients is a more common problems leading to AIDS and death. The objective of this analytical study was to assess the factors associated with failure in treatment of HIV infected pediatric patients. This study conducted by reviewed the medical records of patients who received treatment at Buddhachinaraj Phitsanulok Hospital, between January 2009 to December 2019. There were 72 cases, 36 were female (50%), the median age was 57.5 months, 27 patients (37.5%) had failure in treatment. Four factors found to be related to failure in treatment were the history of patient's caregiver, not the father and/or mother and not a direct relative (p = 0.024), HIV infection status was unknown (p = 0.005), had a history of hospitalization (p = 0.033) and medication discipline less than 95% (p < 0.001). Knowing the effect of HIV infection status preventing treatment failure 0.07 times (AdjOR = 0.07, 95%CI: 0.02-0.30) and having a history of hospitalization increased 3.38 times for treatment failure (AdjOR = 3.38, 95%CI: 1.19-9.58). In conclusion, prevention of failure in treatment of HIV-infected pediatric patients includes having a caregiver promote antiviral drugs and older children or adolescents should be aware of their HIV status
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