Measurements of HDL Cholesterol Particle and Cholesterol Efflux Capacity in Assessment of Cardiovascular Diseases

Abstract

Cardiovascular diseases (CVD) are the first ranking cause of death of the global population. Previous  publications had focused on the increasing of high-density lipoprotein cholesterol (HDL-cholesterol) level  could decrease the CVD events or not. The prevalence of CVD still increased in the normal and high HDL- cholesterol group, indicated that the measurement of HDL-cholesterol was a poor biomarker to predict the  risk of CVD. Therefore, the recent research projects focus on the size and particle of HDL-cholesterol and also  the capacity of HDL-cholesterol, called cholesterol efflux capacity and found the relationship in prevention of  CVD more than the level of HDL-cholesterol. This article provides information between CVD and size, particle  and capacity of HDL-cholesterol for more investigation and considering as a new biomarkers for diagnosis, prevention, and treatment of CVD in the future