Metabolic Syndrome in HIV AIDS Patients Treated at SENA Hospital
Keywords:
Metabolic Syndrome, Antiretroviral Therapy, HIV AIDSAbstract
This retrospective descriptive study aimed to determine prevalence of metabolic syndrome and explore factors associated with metabolic syndrome in HIV/AIDS patient receiving antiretroviral therapy (ART). Samples consisted of 400 HIV patient treated antiretroviral at SENA Hospital. The data were collected during January to March 2018 by the subjects’answers to the questionnaires, reviewing the medical records. Data collection consisted of personal data and health history, medical records, and ART records. The statistics for analyzing data included descriptive statistics, frequency, percentage, mean, standard deviation, range, and odds ratio statistics to investigated factors associated with metabolic syndrome. Metabolic syndrome was defined by the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III).
The results revealed that the prevalence of metabolic syndrome was 32.25%. Metabolic features found in the study, according to the frequency of the feature were row HDL cholesterol (43.50%) high blood pressure (40.25%) hypertriglyceridemia (38.25%) abdominal obesity (34.50%) and hyperglycemia (14.75%). Significant risk factors associated with metabolic syndrome were female gender (OR=1.6; 95%CI=1.08-2.53; p=.030), age ≥45 years (OR=1.6; 95% CI =1.13-2.63; p =.023), body mass Index ≥25 kg/m2(OR=4.5; 95%CI=2.07-4.89; p= .001), CD4 > 400 cell/mm3 (OR=1.9; 95%CI=1.26-3.10; p=.006), ART regimen with Didanosine, Stavudine, Efavirenz or Protease inhibitors (OR=1.9; 95%CI =1.14-3.42; p=.018), and ART duration ≥12 months (OR=2.6; 95%CI=1.15-6.77; p =.032). The results of this study showed that the prevalence of metabolic syndrome in HIV patient receiving ART is relatively high compared to previous studies. Therefore nurse should plan to prevent metabolic syndrome and closely monitored in patients treated with NNRTIs and PI HAART and encouraged HIV patients receiving ART to have appropriate health promoting behaviors to prevent metabolic syndrome which can increase risk for cardiovascular disease.
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