The Study of Factors Associated with Change in Glomerular Filtration Rate over 5 Year among Employees of the Electricity Generating Authority of Thailand

Abstract

     The Follow up study intend to identify factors that associated of the change in estimated glomerular filtration rate in 5-year period of following employees of the Electricity Generating Authority of Thailand. This retrospective cohort study obtained data EGAT 1 and 2 cohort study. This study included 4,835 participants for analysis. The samples were aged between 33-66 years. Changes in estimated glomerular filtration rate were estimated using CKD-EPI creatinine equation. Estimated glomerular filtration rate was classified eGFR into 4 categories: (1) increase >15%, (2) stable within ±15%, (3) minor decline (decline 15-25%), and (4) definite decline (decline >25%). After adjusting for covariates in sex and age group, the multivariable logistic regression model estimated that 5 risk factors associated with the definite eGFR decline significantly in 5 years. The study cohort demonstrated that 1) Education less than 12 year (OR adjusted 1.28, 95%CI 1.07-1.54); 2) Alcohol(Drinking) (OR adjusted 1.56, 95%CI 1.13-2.15); 3) Diabetes (OR adjusted 2.28, 95%CI 1.61-3.23); 4) Hypertension (OR adjusted 1.88, 95%CI 1.39-2.54); and 5) Proteinuria Positive (OR adjusted 1.52, 95%CI 1.16-1.99). All 5 risk factor were related to definite eGFR decline, defined as more than 25% than those who had stable eGFRcr (defined as ±15% change), with p<0.05. This study about the risk factors associated with change in estimated glomerular filtration rate (eGFR) prevent the deterioration of kidney, promote change behavior and reduce risk of complications.