Factors Associated with Multi‐Drug Resistant Acinetobacter baumannii Infections among Patients of the Roi‐Et Hospital Roi‐Et Province

Abstract

The objective of this case‐control study was to assess factors associated with multidrug‐
resistant Acinetobacter baumannii (MDR‐A.baumannii) infections among patients
of the Roi‐Et hospital. The study was conducted between 1 January 2010 to 30 June
2011. Sixty cases with a MDR‐A.baumannii infection and 120 controls without MDRA.
baumannii infection participated in the investigation. Descriptive and inference
statistics used were the Chi‐square univariate analysis and multivariable analysis by
multiple logistic regression. The average age of the cases was 63+17.1 years. Most of
them were males (65.0 %). The average age of the controls was 57+ 16.7 years and 58%
were males. The duration of stay in hospital was 26.2+ 20.3 days for cases and 8.93+ 5.9
days for controls. Factors associated with MDR‐A.baumannii, assessed by multiple
logistic regression, included more than 7 days mechanical ventilation (ORadj=6.01;
95%CI=2.16‐16.69), nasogastric intubation (ORadj=5.07; 95%CI=1.68‐15.29),
endotracheal tubes (ORadj = 4.54; 95% CI=1.51‐13.64) and indwelling urinary catheter
(ORadj=3.45; 95%CI=2.24‐17.4). Factors linked to treatment accounted for prior
antibiotic treatment which Trimethoprimes (ORadj=1.39; 95%CI=1.16‐1.67), Quinolone
(ORadj=1.33; 95%CI=1.14‐1.56), third generation Cephalosporins (ORadj=1.28; 95%CI
=1.13‐1.44), Aminolycoside (ORadj=1.23; 95%CI=1.05‐1.45), Carbapenem (ORadj=1.20;
95%CI=1.04‐1.39) and Piperacillin/Tazobactam (ORadj = 1.18; 95% CI=1.00‐1.39).