Study on Chemical Composition Changes of Cannabis in the Suk Saiyas Formula
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Abstract
Objective: To investigate the changes in the chemical composition of cannabis in the Suk Saiyas formula during storage. Methods: The Suk Saiyas formula, manufactured and quality-controlled by the Division of Traditional and Herbal Medicine Development, was stored at 30°C and 40°C under a relative humidity of 75 ± 5% for 6 months. The contents of the major cannabinoids—tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD)—were quantified using high-performance liquid chromatography (HPLC). Results: The concentration of THC demonstrated a significant decrease under both storage conditions. After 6 months, THC decreased by 19.53% at 30°C and by 24.85% at 40°C. In contrast, the CBN concentration increased substantially, rising by 57.48% at 30°C and by 92.34% at 40°C, indicating the oxidative conversion of THC to CBN, a natural degradation pathway of cannabinoids. The CBD content showed only slight changes, with small increases of 3.17% and 4.29% at 30°C and 40°C, respectively, suggesting high stability of CBD under the tested storage conditions. Conclusion: The findings emphasize the importance of controlling temperature and humidity during storage to preserve the quality and active constituents of the Suk Saiyas formula.
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ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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