Evaluation of Quality of Life and Adverse Event in Head and Neck Cancer Patients Receiving Chemoradiotherapy at Ubon Ratchathani Cancer Hospital
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Abstract
Objective: To evaluate changes in quality-of-life scores and adverse events in patients with head and neck cancer undergoing concurrent chemoradiation. Methods: A prospective cohort study was conducted on patients with head and neck cancer receiving concurrent chemoradiation at Ubon Ratchathani Cancer Hospital. The study assessed quality of life (QOL) using the FACT-H&N version 4.0, while adverse event severity was evaluated by using the CTCAE version 5. The QOL was assessed five times, i.e., before receiving chemoradiation (T1), two weeks after treatment initiation (T2), four weeks after treatment initiation (T4), at the end of treatment (T4) and one month after treatment completion (T5). Results: A total of fifty-one patients were enrolled in this study. The average overall QOL score at T4 (84.55±16.63) was statistically and significantly lower than that at T1 (100.82±14.98) (P < 0.001). Overall QOL in 64.7% of patients reduced more than 12 points indicating clinically significant declines in QOL. Mean overall QOL score at T5 significantly recovered to 99.99 ± 14.70, compared with that at T4 (P < 0.05). The incidence of oral mucositis in patients was 86.30%. The study found a significant association between severity of oral mucositis and QOL decline (P = 0.007). Conclusion: The QOL in head and neck cancer patients who underwent chemoradiotherapy declined compared to that before treatment initiation. However, the QOL showed significant improvement one month post-treatment. The severity of oral mucositis was the factor associated with decline in QOL scores.
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ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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