Development of a Notification System on the Duration of Clopidogrel Prescribing in Patients with Coronary Artery Disease at Sawang Arom Hospital, Uthai Thani Province

Main Article Content

Rawi Jirapan

Abstract

Objective: To develop a notification system for the duration of clopidogrel prescribing according to the indications for patients with ischemic heart disease and to study the effect of the system on the consistency of clopidogrel prescribing with the recommendations in the clinical practice guidelines and the value of clopidogrel prescribed for more than 1 year. Methods: The study consisted of 2 parts. Part 1 was a retrospective study of patients with coronary artery disease who received clopidogrel by collecting the data from the electronic medical record database in the hospital or HOSxP program from January 1, 2021 to December 31, 2021. The data collected included the number of patients with clopidogrel prescribing consistent to the recommendation for each indication, dosage and instruction of use, number of pills prescribed exceeding one year, value of clopidogrel prescribed exceeding one year, and the duration of receiving dual antiplatelet therapy (DAPT). Part 2 studied the results of using the notification system on the duration of drug prescribing and the appropriateness of clopidogrel prescribing from February 1, 2022 to December 31, 2022. Results: After the implementation of the notification system, the percentage of patients who received clopidogrel consistent with the indications increased from 50.94 percent before system implementation to 82.1 percent after system implementation. The average duration of DAPT prescribing reduced from 25.23 months before the system implementation to 12.36 months. The number of pills prescribed exceeding the recommended duration reduced from 21,030 pills before the system implementation to 420 pills, resulting in a decrease in the value of drugs prescribed beyond the recommended duration from 73,605 baht to only 1,470 baht after the system implementation. Conclusion: The implementation of a notification system for the duration of clopidogrel prescribing according to the indications increases drug prescribing in accordance with indications and can reduce the cost of unnecessary drug use.

Article Details

Section
Research Articles

References

Kositchaiwat J. Thai acute coronary syndromes guidelines 2020. Bangkok: Heart Association of Thailand; 2020.

Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease. J Am Coll Cardiol 2016; 68: 1082-115.

Valgimigli M, Bueno H, Byrne RA, Collet JP, Costa F, Jeppsson A, et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for Dual Antiplatelet Therapy in Coronary Artery Disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2018; 39: 213-54.

Byrne RA, Rosello XA, Coughlan JJ, Barbato EM, Berry CO, Chieffo AL et al. 2023 ESC Guidelines for the management of acute coronary syndromes: Developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology. Eur Heart J 2023; 44: 3720-826.

Saneha S, Areepium N. Incidence of gastrointestinal bleeding in thai patients with acute coronary syndrome in concomitant use of dual antiplatelet therapy and proton pump inhibitors. Thai Journal of Pharmacy Practice 2021; 13: 242-50

Public Health Administration. Guidelines for drug management in the service plan: cardiology and nephrology. Nonthaburi: Ministry of Public Health; 2020.

National Drug System Development Committee. Essential drug list B.E.2567 [online]. 2024 [cited Jul 20,2024]. Available from: ratchakitcha.soc.go.th/do cuments/20533.pdf

Iamsiri N, Hayeese W. Consistency of clopidogrel prescribing to its indications for patients with coronary heart disease in Rangae Hospital, Narathiwat. Thai Journal Pharmacy Practice 2022; 14: 219-28.

Klaypaksi A, Polnok A. Effect of computerized clinical decision support system on medication use in patients with renal impairment. Thai Journal of Pharmacy Practice 2020; 12: 437-51.

Jiaxin Yang, Yaodong Ding, Rui Wang, Kexin Wang, Xiaoli Liu, Hua Shen, Yan Sun, Hailong Ge, Zhe Fang. Comparison of short-term DAPT and long-term DAPT on the prognosis of PCI patients: A meta-analysis of randomized controlled trials. Rev Cardiovasc Med 2022; 23: 326.

FDA Drug Safety Communication. FDA Reviews long-term antiplatelet therapy as preliminary trial data show benefits but a higher risk of non-cardiovascular death [online]. 2014 [cited May 1, 2020]. Available from: www.fda.gov/drugs/drug-safe ty-and-availability/fda-drug-safety-communication-fd a-reviews-long-term-antiplatelet-therapy-preliminary-trial-data

Bhatt DL, Cryer BL, Contant CF, Cohen M, Lanas A, Schnitzer TJ, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med. 2010; 363: 1909-17.

Ho PM, Maddox TM, Wang L, Fihn SD, Jesse RL, Peterson ED, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA. 2009; 301: 937-44.

Giustino G, Baber U, Sartori S, et al. Duration of dual antiplatelet therapy after drug-eluting stent implantation: a systematic review and meta-analysis of randomized controlled trials. J Am Coll Cardiol. 2015; 65: 1298-310.