Incidence of Multidrug-resistant Gram-Negative Bacteria in Blood Specimens in a Community Hospital in Northeast
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Abstract
Objective: To study the incidence of multidrug resistant gram negative bacteria (MDR-GNB) in blood specimens and to identify patterns of antibiotic susceptibility in a community hospital in the Northeast. Methods: This research was a descriptive retrospective study using bacterial culture data on blood specimens and the results from antibiotic susceptibility test for the past 5 years from Jan 2016 to Dec 2020. Results: The incidence of MDR-GNB was 28.47% between 2016 and 2020. Annual incidences were 24.83, 21.64, 22.07, 38.08 and 30.86% of isolates with GNB, respectively. The most common strain was Escherichia coli (E. coli) (34.85% of isolates with GNB), followed by Klebsiella pneumoniae (14.19% of isolates with GNB) and Burkholderia pseudomallei (3.19% of isolates with GNB), respectively. The incidence of the majority of MDR-GNB increased. Patients with MDR-GNB were male (52.54%), being aged 60 years and over (57.97%). and hospitalized in female wards (41.02%). Ceftriaxone was the most common used antimicrobial drug in the hospital. Classification of bacteria based on antibiotic resistance revealed E. coli was resistant to penicillins more than any other (98.97%). Conclusion: The incidence of MDR-GNB was likely to increase. Antibiotics use increased, and a higher rate of bacteria with drug resistance in blood specimens was identified. Therefore, the hospital which was the research setting should have a systematic management of information on drug-resistance. There should be a continuous surveillance of drug resistant bacteria and should promote the implementation of antimicrobial stewardship program
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ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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