Autonomic Dysfunctions in Patients with Parkinson’s Disease
Article Sidebar
Main Article Content
Abstract
Objective: To determine the clinical characteristics of autonomic dysfunctions (ADs) in patients with Parkinson’s disease (PD), and to compare the numbers of ADs among those with various personal characteristics, disease severity and drugs. Methods: This study was a cross sectional study in 93 PD patients meeting the inclusion criteria and enrolled into study during September and October 2016 at Chulalongkorn Center of Excellence for Parkinson’s disease and Related Disorders, King Chulalongkorn Memorial Hospital. The researcher assessed AD using the Thammasat University Non-Motor Symptoms Questionnaire (TU-NMSQuest), including gastrointestinal tract problems, urinary tract problems, cardiovascular disorders and falls and sexual disorders. Results: ADs identified in this study included gastrointestinal tract problems (88.17% of subjects), urinary tract problems (59.14% of subjects), cardiovascular disorders and falls (54.84% of subjects) and sexual disorders (16.13% of subjects). Clinical characteristics associated with ADs of gastrointestinal tract were older age and higher severity of PD (higher Hoehn & Yahr stage). ADs of urinary tract problems were related to older age and older age of PD onset. ADs of sexual function were associated with younger age and younger age of PD onset. Analysis of variance did not find any association between various variables and the numbers of ADs. Conclusion: The prevalence of ADs was high rate among patients with PD. Factors associated with ADs of gastrointestinal tract and urinary tract were older age, higher Hoehn & Yahr stage and older age of PD onset. Factors related to ADs of sexual disorders were younger age and younger age of PD onset. However, the association between the variables and the numbers of ADs was not found in this study.
Article Details
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
References
2. Bhidayasiri R, Wannachai N, Limpabandhu S, Choeytim S, Suchonwanich Y, Tananyakul S, et al. A national registry to determine the distribution and prevalence of Parkinson’s disease in Thailand: implications of urbanization and pesticides as risk factors for Parkinson’s disease. Neuroepidemiology 2011; 37: 222-30.
3. Bhidayasiria R, Truong DD. Therapeutic strategies for nonmotor symptoms in early Parkinson’s dis ease: the case for a higher priority and stronger evidence. Parkinsonism Relat Disord 2012; 18: S 110 -3.
4. Martinez-Martin P, Rodriguez-Blazquez C, Kurtis MM, Chaudhuri KR. The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’sdisease. Mov Disord 2011; 26: 399 –406.
5. Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Arvarello TP, et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 2009; 24: 1641–9.
6. Dickson DW, Fujishiro H, Orr C, DelleDonne A, Josephs KA, Frigerio R, et al. Neuropathology of non-motor features of Parkinson disease. Parkinso nism Relat Disord 2009; 15: S1-5.
7. Velseboer DC, Haan RJd, Wieling W, Goldstein DS, de Bie RM. Prevalence of orthostatic hypoten sion in Parkinson's disease: a systematic review & meta-analysis. Parkinsonism Relat Disord 2011; 17: 724-9.
8. Shaw BH, Claydon VE. The relationship between orthostatic hypotension and falling in older adults. Clin Auton Res 2014; 24: 3-13.
9. Isaacson SH, Skettini J. Neurogenic orthostatic hypotension in Parkinson’s disease: evaluation, management, and emerging role of droxidopa. Vasc Health Risk Manag 2014; 10: 169-76.
10. Sithinamsuwan P, Orrawanhanothai P, Thithum K, Udommongkol C, Chairangsaris P, Chinvarun Y, et al. Orthostatic hypotension: a non-motor compli cation assessment in 82 patients with idiopathic Parkinson’s disease in Phramongkutklao Hospital. J Med Assoc Thai. 2010; 93: S93-9.
11. Klanbut S, Phattanarudee S, Wongwiwatthana nukit S, Suthisisang C, Bhidayasiri R. Symptomatic orthostatic hypotension in Parkinson's disease patients: prevalence, associated factors and its impact on balance confidence. J Neurol Sci 2018; 385: 168-74.
12. Pfeiffer RF. Gastrointestinal dysfunction in Parkin son's disease. Parkinsonism Relat Disord 2011; 17: 10-5.
13. Chaudhuri KR, Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, et al. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord 2006; 21: 916-23.
14. Crosiers D, Pickut B, Theuns J, Deyn PP, Van Broeckhoven C, Martinez-Martin P, et al. Non-motor symptoms in a Flanders-Belgian population of 215 Parkinson's disease patients as assessed by the non-motor symptoms questionnaire. Am J Neurode gener Dis 2012; 1: 160-7.
15. Blackett H, Walker R, Wood B. Urinary dysfunc tion in Parkinson's disease: a review. Parkinsonism Relat Disord 2009; 15: 81-7.
16. Lolekha P, Kulkantrakorn K. Non-motor symptoms in Thai Parkinson’s disease patients: prevalence, manifestation and health related quality of life. Neuro Asia. 2014; 19: 163-70.
17. Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE. Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Mov Disord 2010; 25: 2649-85.
18. Vongvaivanich K, Nidhinandana S, Udommong kol C, Chairungsaris P, Chinvarun Y, Wongmek W, et al. Non-motor symptoms in Thai patients with Parkinson's disease studied at Phramongkutklao Hospital. J Med Assoc Thai 2014; 97: S159-67.
19. Sauerbier A, Jitkritsadakul O, Titova N, Klingelho efer L, Tsuboi Y, Carr H, et al. Non-motor symp toms assessed by non-motor symptoms question naire and non-motor symptoms scale in Parkinson 's disease in selected Asian populations. Neuroepide miology. 2017; 49: 1-17.
20. Bae HJ, Cheon SM, Kim JW. Autonomic dysfunc tions in parkinsonian disorders. J Mov Disord 2009; 2: 72-7.
21. Senard JM, Raï S, Lapeyre-Mestre M, Brefel C, Rascol O, Rascol A, et al. Prevalence of orthostatic hypotension in Parkinson’s disease. J Neurol Neu rosurg Psychiatry 1997; 63: 584-9.
22. Uchiyama T, Sakakibara R, Hattori T, Yamanishi T. Short-term effect of a single levodopa dose on micturition disturbance in Parkinson's disease patients with the wearing-off phenomenon. Mov Disord 2003; 18: 573-8.
23. Fasano A, Visanji NP, Liu LW, Lang AE, Pfeiffer RF. Gastrointestinal dysfunction in Parkinson's disease. Lancet Neurol 2015; 14: 625-39.
24. Klingelhoefer L, Jitkritsadakul O, Bhidayasiri R. Objective measurement and monitoring of non motor symptoms in Parkinson's disease. Int Rev Neurobiol 2017;133: 347-87.
25. Okun MS, Walter BL, McDonald WM, Tenover JL, Green J, Juncos JL, et al. Beneficial effects of testosterone replacement for the nonmotor symp toms of Parkinson disease. Arch Neurol 2002; 59: 1750-3.
26. Vilas D, Pont-Sunyer C, Tolosa E. Impulse control disorders in Parkinson's disease. Parkinsonism Relat Disord. 2012; 18: S80-4.
