Development and Safety Testing of Serum Products from Mimosa Left Extract in Normal Volunteers
Keywords:
mimosa, skincare serum, safety testsAbstract
Mimosa (Mimosa pudica L.) is a local plant found throughout Thailand. It has many properties in traditional Thai medical textbooks, and currently, serum skin care products are very popular. Objective: To develop a serum from Mimosa pudica L. leaf extract and study its effectiveness on skin moisture. Method: The active compounds from Mimosa pudica were extracted with 85% ethanol for 7 days using a rotary evaporator. The antioxidant activity of the extract was measured using the DPPH method. Three serum formulas were developed and tested for stability in 7 accelerated conditions at 5 and 45 degrees Celsius. Safety was evaluated, and skin moisture levels were measured using a Corneometer before and after 28 days of using the facial serum product from Mimosa pudica L. leaf extract. The statistics used for data collection included percentage, mean, standard deviation, P-value, and statistical test. Paired-sample t Test and Results: The extract of Mimosa pudica has antioxidant activity with an EC50 value of 30.31±0.06 µg/mL. The standard BHT has an EC50 value of 16.36±0.05 µg/ml. The stability test result indicated that Serum Formula 3 is a clear yellow color. The acidity-alkalinity did not change significantly. The serum texture did not separate. After using the facial serum formula 3 for 28 days, the average moisture value was 46.52±11.51, with a significance level of P<.05. Conclusion: Serum containing Mimosa pudica extract formula 3 has physical and chemical stability, with the best moisturizing effect. It can be further developed into skin care products.
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