Health Product Development from Star Fruit Extract (Averrhoa carambola L.) in Microemulsio
Keywords:
emulgel, microemulsion, star fruit extract, antioxidantAbstract
Star fruit extract is a good source of natural antioxidants, but the research has not been reported about using star fruit extract as the active substance in skin care products. This research aims to develop emulgel by using star fruit extract in microemulsion form. The antioxidant activity was evaluated by the DPPH method. Development from star fruit extract (Averrhoa carambola L.) in microemulsion formulations was plotted on pseudo-ternary phase diagrams. The emulgels with star fruit extract in microemulsion form were formulated and the stabilities of the emulgels were evaluated at room temperature and at accelerated conditions. This study discovered that 1-5% (v/v) star fruit extract has 48.33-88.48% free radical scavenging activities and a IC50 of 1.062% (v/v). The appropriate microemulsion formula consists of 20%-star fruit extract, 5% isopropyl alcohol, 25% Jojoba oil, 25% Span 80, and 25% Tween 80. The emulgels with 2.5–7.0% (w/w) star fruit extract in microemulsion form have stability at room temperature and under accelerated conditions. The pH and viscosity of these emulgels were in the range of 5.87–6.05 and 73x103-184x103 Cps., respectively. Therefore, the emulgel with star fruit extract in microemulsion form formulas is possible to use as a skin care product.
References
Burns, J., Rivers, J. M., & Machlin, L. J. (1987). Third conference on vitamin C. In Conference on Vitamin C 1986: New York, NY. New York: Academy of Sciences.
Chang, J. M., Hwang, S. J., Kuo, H. T., Tsai, J. C., Guh, J. Y., Chen, H. C., & Lai, Y. H. (2000). Fatal outcome after ingestion of star fruit (Averrhoa carambola) in uremic patients. American Journal of Kidney Diseases, 35(2), 189-193. https://doi.org/10.1016/s0272-6386(00)70325-8
Gu, Z. P., Zhang, S. M., Wang, C. L., Lian, W. Y., Xiao, P. G., & Chen, J. M. (1997). Determation of strychnine and brucine in Strychnos by HPLC. Yao xue xue bao= Acta pharmaceutica Sinica, 32(10), 791-794. PMID: 11596226.
Greul, A. K., Grundmann, J. U., Heinrich, F., Pfitzner, I., Bernhardt, J., Ambach, A., Biesalski, H. K., & Gollnick, H. (2002). Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacology and Applied Skin Physiology, 15(5), 307–315. https://doi.org/10.1159/000064534
Janyaprasert, W. (2012). Nanotechnology in skin delivery (4th ed.) Bangkok: Chum Chum Printing House Agricultural Cooperatives of Thailand Limited. (in Thai)
Junyaprasert, V. (2009). Nanotechnology: Skin delivery of drugs and cosmetics. Bangkok: Prachachon. (in Thai)
Khanam, Z., Sam, K. H., Zakaria, N. H. B. M., Ching, C. H., & Bhat, I. U. H. (2015). Determination of polyphenolic content, HPLC analyses and DNA cleavage activity of Malaysian Averrhoa carambola L. fruit extracts. Journal of King Saud University-Science, 27(4), 331-337. https://doi.org/10.1016/j.jksus.2015.01.004
Krasantisuk, S., & Runnarong, H. (2006). The development of skin care sericin lotion. The Southern College Network Journal of Nursing and Public Health, 4(3), 249-258. (in Thai)
Masuda, T., & Jitoe, A. (1994). Antioxidative and antiinflammatory compounds from tropical gingers: Isolation, structure determination, and activities of cassumunins A, B, and C, new complex curcuminoids from Zingiber cassumunar. Journal of Agricultural and Food Chemistry, 42, 1850-1856. https://doi.org/10.1021/jf00045a004
Saikia, S., Mahnot, N. K., & Mahanta, C. L. (2015). Optimisation of phenolic extraction from Averrhoa carambola pomace by response surface methodology and its microencapsulation by spray and freeze drying. Food chemistry, 171, 144–152. https://doi.org/10.1016/j.foodchem.2014.08.064
Shui, G., & Leong, L. (2006) Residue from star fruit as valuable source for functional food ingredients and antioxidant nutraceuticals. Food Chemistry, 97, 277-284. http://dx.doi.org/10.1016/j.foodchem.2005.03.048
Sohail, M., Naveed, A., Abdul, R., Gulfishan, Muhammad Shoaib Khan, H., & Khan, H. (2018). An approach to enhanced stability: Formulation and characterization of Solanum lycopersicum derived lycopene based topical emulgel. Saudi Pharmaceutical Journal: SPJ: The Official Publication of the Saudi Pharmaceutical Society, 26(8), 1170–1177. https://doi.org/10.1016/j.jsps.2018.07.005
Tanaji, D. N. (2018). Emulgel: A comprehensive review for topical delivery of hydrophobic drugs. Asian Journal of Pharmaceutics, 12(02), s382-s393. https://doi.org/10.22377/ajp.v12i02.2366
Vertuani, S., Angusti, A., & Manfredini, S. (2004). The antioxidants and pro-antioxidants network: An overview. Current Pharmaceutical Design, 10(14), 1677–1694. https://doi.org/10.2174/1381612043384655
Vinson, J. A.; Dabbagh, Y. A., Serry, M. M., & Jang, J. (1995). Plant flavonoids, especially tea flavonols, are powerful antioxidants using an in vitro oxidation model for heart disease. Journal of Agricultural and Food Chemistry, 43, 2800-2802. https://doi.org/10.1021/jf00059a005
