Effects of Dialyzer Reuse with Different Molecular Sizes of Particles on the Membrane Filtration Efficiency during Hemodialysis Process
Keywords:
Hemodialysis, Dialyzer reuse, Diffusion process, ClearanceAbstract
This research investigated the mass transfer behaviors through a dialyzer in the hemodialysis process. The objective of this research was to study the effects of dialyzer reuse on filtration efficiency by using the different molecular sizes of particles. The clearance was used to determine the filtration efficiency of each dialyzer. Urea and maltodextrin solutions were chosen as test solutes, while RO water was used as a dialysate. The solution and RO water were allowed to flow in a parallel direction through a dialyzer. The blood-side flow rate was set at 300 ml/min and the dialysate-side flow rate was varied until the inlet pressure difference between the blood side and dialysate side was almost zero. The different types of dialyzer including FINEFLUX FIX-210S eco, ELISIO-210HR, and PEPA FDY-21B, were examined. These dialyzers were used in chronic kidney disease patients for 0, 1, 3, 5, and 7 times. It was found that when the number of reuses increased, the trend of the outlet urea concentration was decreased, resulting in higher urea clearance. On the other hand, the trend was reversed for maltodextrin. The FINEFLUX FIX-210S eco dialyzer was found to be more effective in filtering out these particles than other dialyzers. The clearance results obtained were reasonably supported by the surface characteristics of the dialyzer membranes. Even though all dialyzer types have been reused seven times, these dialyzers have a high filtering efficiency and are more reusable.
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