Diagnostic Guidelines for Dengue Fever Based on Hematological Parameters in the Laboratory of Ban Mi Hospital
Keywords:
Diagnostic approach, Dengue fever, Hematological parametersAbstract
This descriptive-analytical study aimed to establish preliminary diagnostic guidelines for dengue hemorrhagic fever (DHF) using haematological parameters measurable in community hospital laboratories. The study also analyzed differences in these parameters between dengue patients and healthy controls, and investigated the correlation between these values and the level of disease severity. Haematological data measured by a Beckman Coulter DXH600 analyzer were retrospectively collected from the medical records of 55 confirmed dengue patients and 64 healthy control subjects at Ban Mi Hospital, Lopburi Province, during 2023. Data were analyzed using the independent t-test to assess differences between the groups and the Chi-square test to examine correlations.
The analysis demonstrated statistically significant differences (p < 0.05) between the dengue patient group and the control group in several parameters: White Blood Cell Count (WBC, p = 0.000), Neutrophil (p = 0.028), Lymphocyte (p = 0.015), Eosinophil (p = 0.000), Mean Corpuscular Hemoglobin Concentration (MCHC, p = 0.011), and Platelet Count (p = 0.000). Notably, a marked decrease in both WBC and Platelet counts was observed in the patients. Furthermore, the Eosinophil count was found to be significantly correlated with the level of disease severity (p = 0.029)
The findings suggest that specific haematological parameters, especially WBC, Platelet, and Eosinophil counts, can serve as valuable indicators for the preliminary diagnosis of DHF in primary healthcare facilities. It is recommended that these haematological findings be interpreted in conjunction with the patient’s clinical presentation and epidemiological data to maximize diagnostic accuracy.
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