Risk Factors for the Development of Tuberculosis in People Living with HIV in Khlong Luang Hospital
Keywords:
HIV, Risk factors, TuberculosisAbstract
The mortality rate of people living with HIV (PLWH) and infected with tuberculosis increases each year. This analytical case-control study aimed to investigate risk factors for tuberculosis infection among PLWH. The study was conducted among PLWH receiving care at Klong Luang Hospital, Pathum Thani Province, from October 1, 2019, to September 30, 2023. Statistical analysis was performed using Chi-square and multiple logistic regression.
The study compared two groups: 60 PLWHs with tuberculosis and 120 PLWHs without tuberculosis. The result showed that risk factors for tuberculosis among PLWHs includedage of under 30 years (OR=2.21, 95% CI 1.02–4.81), alcohol consumption (OR=4.00, 95% CI 1.69–9.49, p=0.002), initial CD4 level less than 50 cells/mm3 (OR=2.57, 95% CI 1.19–5.55, p=0.016) and 51-100 cells/mm3 (OR=2.24, 95% CI 1.56–4.76, p=0.036), HIV viral load greater than 20 copies/ml (ORadj=2.61, 95% CI 1.18–5.74, p=<0.018), weight less than 50 Kg (ORadj=2.65, 95% CI 1.25–5.64, p=0.010), and a history of previous infection (OR=4.85, 95% CI 2.18–10.77). PLWHs at high risk of developing tuberculosis are a group that requires enhanced care to reduce mortality rates.
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