Clinical Impact of Antibiotics Use in Hospitalized Children with Acute Pneumonia
Keywords:
Antibiotics, Acute pneumonia, Complications, Intubation rate, Standardized costAbstract
Acute pneumonia is the most leading cause of hospitalized children which widely common used difference kinds of antibiotics in treatment regardless of scientific evidences. This retrospective analytic study aimed to compare clinical impact between narrow-spectrum versus broad-spectrum antibiotics in hospitalized children with acute pneumonia. This retrospective cohort study was conducted in hospitalized children with acute pneumonia who were admitted from 2018 -2021. The patients were divided into two groups: narrow-spectrum and broad-spectrum.
Among 589 patients, 41% were empirically treated with a narrow-spectrum agent and 59% with a broad-spectrum agent. In the adjusted analysis, the narrow-spectrum group had a lower intubation rate than the broad-spectrum group (P=0.026). Moreover, the narrow-spectrum group had 13-hour (P=0.001), 7-hour (P=0.001) and 1 day (P=0.002) shorter duration of oxygen, fever and length of stay, respectively. There was no significant difference in readmission. The average standardized cost was lower than 3,438 baht in the narrow-spectrum group (P=0.001), but antibiotic associated diarrhea was commonly found in the broad-spectrum group (P=0.001).
The effectiveness of narrow-spectrum agents was comparable to broad-spectrum agents since they had a lower intubation rate, a shorter duration of oxygen, fever, length of stay, lower hospitalized cost, and lower incidence of antibiotic associated diarrhea.
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