Factors Associated with Pretreatment Neutrophils to Lymphocytes Ratio Equal to or More Than 3 in Cervical Cancer Patients

Abstract

To identify factors associated with the neutrophils to lymphocytes ratio equal to or more than 3 in patients in Chaophrayayommaraj Hospital, Suphanburi Province. This retrospective cohort study collected data which were medical records of cervical cancer patients from 1 January 2012 to 31 October 2021. The demographic data, tumor factors, and complete blood count (CBC) were collected and analyzed using SPSS version 26.

The study focused on 84 patients. The mean age was 55.86 years. Tumor size was associated with NLR ≥3 and the odd ratio was 3.084 95%CI (1.436-10.078). Lymph node involvement was associated with NLR ≥3 and the odd ratio is 2.530 95%CI (1.018-6.285). Hemoglobin level was associated with NLR ≥3 and the odd ratio is 4.909 95%CI (1.794-13.431). The locally advanced stage was associated with NLR ≥3 and the odd ratio is 3.214 95%CI (1.180-8.757). After performing multivariate analysis, lymph node involvement and Hb level < 10 gm/dL were associated with NLR≥3; OR 2.628 95%CI (1.048-6.589) and 4.174 95%CI (1.494-11.515), respectively.

The neutrophils to lymphocytes ratio equal to or more than 3 was associated with lymph node involvement status and hemoglobin level < 10 gm/dL. These results could probably predict the prognosis of the disease if data of response and survival rates are collected.