Outcome of Administration of Vasopressors in Septic Shock
Keywords:
Norepinephrine, septic shockAbstract
Introduction: The pathophysiology of septic shock is complex. Recently, although the advances management of septic shock is improvement, the mortality remains unacceptably high. On the other hand, the key therapies, including appropriate antimicrobials and fluid resuscitation appears to reduce the mortality. This study examined whether early initiation of vasopressor therapy is associated with improved survival.
Material and Method: We conducted a retrospective cohort study at Sing Buri hospital of eligible 320 subjects were hospitalized and had documented septic shock between 30 June 2015 to 30 June 2017. The primary outcome was mortality rate. The secondary outcomes were length of hospital and ICU stay, duration of ventilator support, renal support and vasopressor dependence.
Result: In total, 442 patients met the definition of septic shock. Of these, 320 were suitable for analysis. There were 160 patients in both Early-NE and Late-NE group. Mortality rate was 31.9% in early-NE group and 86.9% in late-NE group (P<0.000). No statistically significant in length of hospital and ICU stay, duration of ventilator support, renal support and vasopressor dependence between Early-NE and Late-NE groups.
Conclusion: Early administration of norepinephrine in septic shock patients is associated with a decreased mortality rate.
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