Comparison of Traditional and Reverse Syphilis Screening Algorithms in Pregnant Woman at Samutprakarn Hospital

Abstract

Objective: To compare the performance of traditional and reverse syphilis screening algorithms in pregnant women at Samutprakarn Hospital

Method: Blood samples were collected from 882 pregnant women who received antenatal care from November 2019 to August 2020. The specimens were tested by using the rapid plasma regain (RPR) method and the cobas e 601 module, a fully automated analyzer for electrochemiluminescent  immunoassays(ECLIA).All testing was performed according to instructions recommended by the manufacturer. Statistical analyses were performed using Bionomial Test and Chi-square Test.

Result: The result revealed that the traditional and the reverse syphilis screening algorithms performed positive and consistent results in 13 samples. However, 11 samples had positive results using the reverse algorithm but negative results using the traditional one. The reverse algorithm significantly performed positive results and was more accurate than the traditional algorithm. 

Conclusion: This study indicated that the reverse syphilis screening algorithm would be more efficient in screening for syphilis in pregnant women than the traditional one.