Optimization of single donor platelet (SDP) preparation to improve cost-effectiveness while ensuring product quality and donor safety at the Blood Donation Center, Chiangrai Prachanukroh Hospital
Article Sidebar
Main Article Content
Abstract
BACKGROUND: Single Donor Platelet (SDP) plays a crucial role in treating patients with thrombocytopenia who require a large volume of platelets. Preparing platelets as a double dose per donation can increase the platelet inventory and reduce costs. However, Chiangrai Prachanukroh Hospital still lacks systematic data to optimize the collection of double-dose platelets effectively.
OBJECTIVE: To study the current situation of platelet donation and develop guidelines for double-dose platelet collection in eligible donors, as well as to evaluate the effectiveness of double-dose platelet preparation, product quality, donor safety, and cost-effectiveness of platelet preparation.
METHODS: This prospective cross-sectional study was conducted at the Blood Donation Center, Chiangrai Prachanukroh Hospital, involving 220 eligible double-dose platelet donors. Group differences were analyzed using t-tests and exact probability tests.
RESULTS: The study found that donors met the platelet count criteria for double-dose donation, but only 61.8% were able to donate as such. The primary reason for switching to single-dose donation was time constraints (63.1%), while the main motivation for donation was altruism(91.2%). Donors in the double-dose group had significantly higher body weight and pre-donation platelet counts (p<0.05 and p<0.001), yielded a greater platelet volume, required longer preparation time, and retained higher white blood cell counts than the single-dose group (p<0.001). No significant differences in adverse events were observed, and cost analysis showed a 50% reduction in average cost per unit, saving a total of 994,180 THB.
CONCLUSIONS AND RECOMMENDATIONS: This study confirms that promoting double-dose platelet donation is a cost-effective, efficient, and safe approach to increasing the platelet inventory at Chiang Rai Prachanukroh Hospital. The resulting products meet quality standards, and the findings provide a key basis for developing donor recruitment systems, planning to expand platelet reserves, and designing future public awareness strategies.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
National Blood Centre, Thai Red Cross Society. Blood donation manual. Bangkok: Nam Aksorn; 2021.
Eernisse JG, Brand A. Prevention of platelet refractoriness due to HLA antibodies by administration of leukocyte-poor blood components. Exp Hematol. 1981;9(1):77-83.
National Blood Centre, Thai Red Cross Society. Standard for blood bank and transfusion services. 5th ed. Bangkok: Udomsuksa; 2024.
American Red Cross [Internet]. Washington (DC): American Red Cross; c2024. Platelets; c2024 [cited 2025 May 31]. Available from: https://www.redcrossblood.org/biomedical-services/blood-products-and-services/platelets.html
U.S. Food and Drug Administration [Internet]. Maryland: Food and Drug Administration; 2025. Guidance for industry and FDA review staff: Collection of platelets by automated methods;2007[cited2025 May 31]. Available from: http://www.fda.gov/cber/guidelines.htm
Soloslikit W, Vienghok P. Effectiveness of double dose in single donor platelet preparation by the automated blood cell separators in continuous and intermittent flow system. Bull Chiang Mai Assoc Med Sci. 2016; 49(3): 400-411.
Nonsee N, Yingsitsiri W, Kidhen B, Chawalchitiporn S. Efficacies and cost evaluation of double dose plateletpheresis in additive solution by blood cell separator between continuous and intermittent flow system. Cancer Sci Res. 2020; 3(2): 1-6.
Pochailert U. Factors influencing public consciousness about blood donation in
Thailand. [dissertation]. Bangkok: Thammasat University; 2015.
Jorgensen J, Sorensen BS. Donor vigilance. ISBT Science Series 2008;3:48-52.
Bednall TC, Bove LL. Donating blood: a meta-analytic review of self-reported motivators and deterrents. Transfus Med Rev. 2011;25(4):317–34.
Wollersheim J, Dautzenberg M, van de Griendt A, Sybesma B. Donor selection criteria to maximize double platelet products (DPP) by platelet apheresis. Transfus Apher Sci. 2006;34(2):179–86.
Chopra S, Kaur P, Bedi RK, Kaur G. Effect of double dose plateletpheresis on target yield and donor platelet recovery. Hematol Transfus Cell Ther. 2023;45(1):16-24.
