Preliminary Study on Effect and Safety of Roselle Extract Tablets for Treating Patient with Stage 1 Hypertension
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Abstract
Objective: To preliminarily investigate efficacy and safety of Roselle extract 500 mg in patients with stage 1 hypertension having 140-159 mmHg of systolic blood pressure and 90-99 mmHg of diastolic blood pressure. Methods: The study design was quasi-experimental research in 20 volunteers with stage 1 hypertension. Subjects took 125 mg Roselle extract tablets twice a day before breakfast and dinner (500 mg/day) for a period for 12 weeks. The study measured subjects’ blood pressure at week 4, 8, 12 to evaluate the efficacy of the extract, and assessed its safety by testing liver and renal functions. Results: Systolic blood pressure of the subjects after taking the Roselle extract tablets significantly decreased from 151.2 ± 6.4 mmHg in the week 0 to 141.4 ± 10.3 mmHg and 140.9 ± 11.2 mmHg at week 4 and 12, respectively, with no effects on liver and renal functions. Roselle extract tablets was effective in lowering systolic blood pressure since the 4th week of treatment. Conclusion: The use of Roselle extract tablets 500 mg/day was effective in lowering systolic blood pressure levels and safe without effects on renal and liver functions. The results of this study support further comparative research on the effectiveness of Roselle extract tablets and western anti-hypertensive drugs in order to support the use of herbal medication prior to modern medicine.
Article Details
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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