Urinary Cannabis Metabolite Detections in Suspects and Postmortem Cases Before and After the Notification of the Narcotics Act B.E. 2565

Authors

  • Theerin Sinchai Department of Forensic Toxicology, Institute of Forensic Medicine, Police General Hospital
  • Rawikorn Thararattanobon Department of Forensic Toxicology, Institute of Forensic Medicine, Police General Hospital
  • Pongsathorn Kontawan Department of Forensic Toxicology, Institute of Forensic Medicine, Police General Hospital
  • Suksan Sresomboon School of Pharmacy, Eastern Asia University
  • Nipaporn Kedchoy School of Pharmacy, Eastern Asia University
  • Sasikanok Sooklarp School of Pharmacy, Eastern Asia University
  • Somsong Lawanprasert School of Pharmacy, Eastern Asia University

Keywords:

cannabis, manner of death, narcotics act

Abstract

Cannabis contains substantial amounts of the psychoactive substance delta-9-tetrahydrocannabinol --Δ9-THC, which is primarily responsible for the effects of marijuana on a person’s mental state, which could lead to an unnatural death. This study aims to evaluate the incidence of cannabis metabolite detections in urine samples of suspects and corpses. The association between the manner of unnatural death and the findings of the main cannabis metabolites in postmortem cases six months before and after the notification of the Narcotics Act B.E. 2565 was examined. The retrospective data was collected from laboratory results of suspects and postmortem cases whose urine samples were determined for narcotic or psychoactive substances at the Institute of Forensic Medicine, Police General Hospital, from December 1, 2021, to December 31, 2022. The result revealed 81 cases (2.75%) of positive cannabis metabolites in urine samples out of 2,942 cases. Among these positive cases, 32 cases (2.32%) were from the urine samples collected 6 months before the notification of the Narcotics Act B.E. 2565 (December 1, 2021 to June 8, 2022), and 49 cases (3.13%) were from 6 months after canceling cannabis from the drugs of abuse list (June 9, 2022 to December 31, 2022). Most of the positive cases were males of Thai nationality, aged between 18 and 59 years old. There was no significant difference in co-substance use before and after the law took place. The main manner of death in this study was unknown, followed by accidental death. It was shown that during the six months after the cancellation, the incidence of positive cannabis cases of all manners of death was higher than that of the six months before the cancellation. However, when using the Fisher’s exact test, it was found that the incidence of positive cannabis cases during the 6 months before and 6 months after the cancellation was not significantly associated with the manner of death. Additional study with a longer period of time for sample collection is suggested.

References

Asbridge, M., Hayden, J. A., & Cartwright, J. L. (2012). Acute cannabis consumption and motor vehicle collision risk: Systematic review of observational studies and meta-analysis. British Medical Journal, 12, 344, e536. https://doi.org/10.1136/bmj.e536

Ashton, C. H. (2001). Pharmacology and effects of cannabis: A brief review. The British Journal of Psychiatry: The Journal of Mental Science, 178, 101–106. https://doi.org/10.1192/bjp.178.2.101

Borst, J. M., Costantini, T. W., Reilly, L., Smith, A. M., Stabley, R., Steele, J., Wintz, D., Bansal, V., Biffl, W. L., & Godat, L. N. (2021). Driving under the influence: a multi-center evaluation of vehicular crashes in the era of cannabis legalization. Trauma Surgery Acute Care Open, 6, e000736. doi:10.1136/tsaco-2021-000736

Carvalho, A. F., Stubbs, B., Vancampfort, D., Kloiber, S., Maes, M., Firth, J., Kurdyak, P. A., Stein, D. J., Rehm, J., & Koyanagi, A. (2019). Cannabis use and suicide attempts among 86, 254 adolescents aged 12-15 years from 21 low-and middle-income countries. European Psychiatry: The Journal of The Association of European Psychiatrists, 56, 8–13. https://doi.org/10.1016/j.eurpsy.2018.10.006

Narcotics Act B.E. 2564, (2021, 8 November). The Royal Thai Government Gazette. Volume. 138 Part 73, pp. 1-80. Retrieved from https://songkhla.moj.go.th/attachments/20220225121008_76784.PDF (in Thai)

Nicolas, A. C. S., & Lemos, N. P. (2015). Toxicology findings in cases of hanging in the city and county of San Francisco over the 3-year period from 2011 to 2013. Forensic Science International, 255, 146–155. doi: 10.1016/j.forsciint.2015.07.006

Official Announcement of the Ministry of Health, (2022, 9 Feb). The Royal Thai Government Gazette. Volume. 139 Part 35, p. 8. Retrieved from http://www.ratchakitcha.soc.go.th/DATA/PDF/2565/E/035/T_0008.PDF. (in Thai)

Official Announcement of the Narcotic Control Board, (2020, 17 Jul). The Royal Thai Government Gazette. Volume. 137 Part 164, pp. 18-22. Retrieved from http://www.ratchakitcha.soc.go.th/DATA/PDF/2563/E/164/T_0018.PDF. (in Thai)

Ramaekers, J. G., Berghaus, G., van Laar, M., & Drummer, O. H. (2004). Dose related risk of motor vehicle crashes after cannabis use. Drug and Alcohol Dependence, 73(2), 109–119. https://doi.org/10.1016/j.drugalcdep.2003.10.008

Sinchai, T., Tungtananuwat, W., O-chongpian, P., Manitsirikul, S., Chaywan, P., & Lawanprasert, S. (2022). Association between the findings of cannabis metabolites and manner of unnatural death in postmortem cases at the Institute of Forensic Medicine, Police General Hospital. EAU Heritage Journal Science and Technology, 16(2), 78-90. (in Thai)

Sharma, P., Murthy, P., & Bharath, S. (2012). Chemistry, metabo lism, and toxicology of cannabis: Clinical implications. Iran Journal of Psychiatry, 7(4), 149-156. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570572/pdf/IJPS-7-149.pdf

Surveillance network on drugs of abuse problem by detecting drugs of abuse from forensic medicine/forensic science. (2021). Annual report of the epidemiological surveillance of drugs of abuse in forensic medicine according to the national security strategy. Retrieved from https://nctc.oncb.go.th/manage/researchMgt/import/researchFull/20220908_140703ONCB.pdf. (in Thai)

The Act Promulgating the Panel Code B.E. 2477, (1934, 7 March). The Royal Thai Government Gazette. Volume. 52 Part 2, pp. 52-53. Retrieved from http://web.krisdika.go.th/data/law/law4/%BB05/%BB05-20-9999-update.pdf. (in Thai)

Whitehill, J. M., Harrington, C., Lang, C. J., Chary, M., Bhutta, W. A., & Burns, M. M. (2019). Incidence of pediatric cannabis exposure among children and teenagers aged 0 to 19 years before and after medical marijuana legalization in Massachusetts. JAMA Network Open, 2(8): e199456. doi:10.1001/jamanetworkopen.2019.9456

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Published

2024-04-26

How to Cite

Sinchai, T. ., Thararattanobon, R. ., Kontawan, P. ., Sresomboon, S. ., Kedchoy, N. ., Sooklarp, S. ., & Lawanprasert, S. (2024). Urinary Cannabis Metabolite Detections in Suspects and Postmortem Cases Before and After the Notification of the Narcotics Act B.E. 2565. EAU Heritage Journal Science and Technology (Online), 18(1), 134–144. retrieved from https://he01.tci-thaijo.org/index.php/EAUHJSci/article/view/263866

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Research Articles