Skin Cream Containing Ganoderma lucidum Root Extract to Increase Skin Elasticity in The Elderly, Sa Kaeo Province
Keywords:
Ganoderma lucidum extract, antioxidant, trans epidermal water loss, skin elasticityAbstract
Ganoderma lucidum contains substances that have high antioxidant potential. Phenolic compounds such as terpenes (triterpenoids) and polysaccharides are substances that have high antioxidant properties and are used as active ingredients in health products. The objective of this research was to determine the efficacy of a lotion product containing Ganoderma lucidum root extracts to increase skin elasticity in the elderly in Sa Kaeo Province. This research investigated the antioxidant activity of Ganoderma lucidum root extracts by the DPPH method. The extracts were used to develop a lotion product containing Ganoderma lucidum root extracts and study product stability. The results of the study showed that Ganoderma lucidum root extract had an antioxidant activity with an IC50 value of 0.78 mg/mL. Lotion products containing 10% Ganoderma lucidum extract were stable at room temperature and under accelerated conditions with both light and no light exposure. The texture of lotion is smooth, quite viscous, a light yellow color, odorless, has no separation, feels cool, and absorbs quickly when applied. According to the findings of a product safety study using the closed patch test method, lotion products
do not cause allergic reactions in the skin (the mean irritation index, M.I., was 0.00). After using the product for 4 weeks, lotion products can increase skin elasticity in volunteers. Skin elasticity coefficients R2 (total skin elasticity), R5 (net skin elasticity), and R7 (elastic recovery ratio) were considered. The comparison of skin elasticity before and after using the product found that elasticity increased statistically significantly (p-value < 0.05). Therefore, products containing Ganoderma lucidum root extract can be used as skin care products that increase skin elasticity.
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