Safety and Effectiveness Study of Formulation Containing Rice Bran Oil with Gamma Oryzanol 18,000 ppm in Improving Skin Barrier Function and Moisturization for Dry Skin
Keywords:
dry skin, barrier function, invivo test, safety test, closed patch test, transepidermal water loss, moisturizing effect, irritationAbstract
Dry skin is a delicate skin type. Easy to be threatened by external factors, UV radiation, chemicals, germs due to the protective barrier of dry skin is quite weak. When losing the strength of the protective shell, there will be a chance of losing important substances within the skin, resulting in degeneration of the skin. The aim of this study was to do safety test and the effectiveness of increasing the strength of the skin barrier function, skin moisturization and formulation satisfaction. Using formulation containing Rice Bran Oil--RBO with gamma oryzanol 18,000 ppm , 10% w/w concentration, 15% w/w and 20% w /w, respectively. Using closed patch test for safety 48 hours in total 30 female and male volunteers with dry skin, 20-50 years old. Evaluate Transepidermal Water Loss--TEWL values from the skin using the Tewameter® TM210, study of short-term skin hydration (6 hours) and long-term (4 weeks) using the Corneometer® CM 825. It was found that. RBO formulations containing gamma oryzanol 18,000 ppm at the concentration 10% w/w, 15% w/w and 20% w/w, can improve skin barrier functions and skin hydration including short-term and long-term hydration. All 3 formulations reduced TEWL after using the product for 4 weeks (p=.001), and all 3 formulations can be maintained moisturization at 6 hours. The 2 formulations with RBO at 15% w/w and 20% w/w can increase moisture after using the product for 2 weeks (p=.001).
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