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This article illustrates the basic knowledge on Plant Factory with Artificial Lighting (PFAL) technology. That is the application of plant physiology technology, agriculture and agriculture engineering for farming. Soilless culture technique is applied in greenhouse or building in closed system that controls key factors for plant growth including temperature, relative humidity, both of macronutrients and micronutrients, carbon dioxide and artificial lighting. The artificial lighting uses a light source from LED bulbs. It can control the quantity and quality of light which are suitable for the growth of plants, gives low heat and saves energy. In Thailand PFAL is suitable for the agriculture of high price vegetables and high value medicinal herbs for health products (medicines, cosmetics, supplements), also stimulates plant growth to increase quality and productivity using various technologies involved in control of the cultivation environment to add some plant properties. This will be help farmers to earn higher income and generate income of Thailand in the future.