Clinical Effects of a Mixture Capsule Containing Hibiscus Sabdariffa L. (Rosella) and Lippia Citriodora L. (Lemon Verbena) on Obesity Treatment: A Systematic Review and Meta-analysis
Keywords:
Hibiscus sabdariffa L., Lippia citriodora L., obesity, overweightAbstract
The purpose of this systematic review and meta-analysis was to determine the efficacy and safety of a mixture capsule of Hibiscus sabdariffa L. (Rosella) and Lippia citriodora L. (Lemon Verbena) extracts on obesity treatment. Randomized controlled trials (RCT) from PubMed, Embase, and the Cochrane central register of clinical trial (CENTRAL) were searched from the start of each database until March 2023. RCTs studies about the effects of Hibiscus sabdariffa L. and Lippia citriodora L. combination products on obesity treatment were included for subjects aged ≥18 years old who had body mass index (BMI) ≥ 23 kg/m2 or had been diagnosed with being overweight or obese; and reported one of the following clinical outcomes: 1) body weight, 2) BMI, or 3) waist circumference. The quality of the included RCTs was assessed using the Cochrane Risk of Bias version 2 (RoB 2). The results were analyzed under a random-effects model and reported as mean differences (MD) with 95% confidence intervals (95%CI). The Review Manager 5.4 (RevMan 5.4) was used for statistical analysis. The results showed as follows.
1. The intervention group could significantly reduce waist circumference (MD = -4.59 cm, 95%CI = -9.01, -0.16). However, these combination products have no effects on BMI and body weight compared to the placebo group.
2. No adverse events were reported.
This current evidence demonstrated that combination products of Hibiscus sabdariffa L.and Lippia citriodora L.could reduce waist circumference, with no safety concerns. However, further high-quality trials are needed to enhance the confidence of the generated evidence.
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