การพบเชื้อพอร์ไฟโรโมแนส จิงจิวาลิสในรกหญิงตั้งครรภ์ที่คลอดก่อนกำหนด
คำสำคัญ:
พอร์ไฟโรโมแนส จิงจิวาลิส, การคลอดก่อนกำหนด, รกบทคัดย่อ
เชื้อพอร์ไฟโรโมแนส จิงจิวาลิส เป็นแบคทีเรียที่มีความสัมพันธ์กับโรคปริทันต์ สามารถพบได้ภายในช่องปาก ในปัจจุบันมีการรายงานว่าสามารถพบเชื้อชนิดนี้ในอวัยวะต่างๆ ของร่างกายและมีความสัมพันธ์กับโรคทางระบบอื่นๆ รวมถึงการคลอดก่อนกำหนด การศึกษานี้มีวัตถุประสงค์เพื่อตรวจหาเชื้อพอร์ไฟโรโมแนส จิงจิวาลิส ในรกของหญิงตั้งครรภ์ ทำการเก็บชิ้นรกจากหญิงตั้งครรภ์ที่คลอดตามเกณฑ์ปกติ 10 คนและหญิงตั้งครรภ์ที่คลอดก่อนกำหนด 10 คนหลังคลอด จากนั้นนำรกมาสกัดดีเอ็นเอของแบคทีเรีย นำไปทดสอบการพบเชื้อพอร์ไฟโรโมแนส จิงจิวาลิส ด้วยวิธีปฏิกิริยาลูกโซ่พอลิเมอเรส ผลการศึกษาพบว่าสามารถตรวจพบเชื้อพอร์ไฟโรโมแนส จิงจิวาลิส ในรกของหญิงตั้งครรภ์ที่คลอดก่อนกำหนด และในรกของหญิงตั้งครรภ์ที่คลอดตามเกณฑ์ปกติ โดยไม่พบความแตกต่างอย่างมีนัยสำคัญทางสถิติ (P > 0.05)
References
1. Socransky S, Haffajee A, Cugini M, Smith C, Kent R. Microbial complexes in subgingival plaque. J Clin Periodontol 1998; 25(2): 134-44.
2. Vernal R, Díaz-Zúñiga J, Melgar-Rodríguez S, Pujol M, Diaz-Guerra E, Silva A, et al. Activation of RANKL-induced osteoclasts and memory T lymphocytes by Porphyromonas gingivalis is serotype dependant. J Clin Periodontol 2014; 41(5): 451-9.
3. Kato H, Taguchi Y, Tominaga K, Umeda M, Tanaka A. Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells. Arch Oral Biol 2014; 59(2): 167-75.
4. Travis J, Pike R, Imamura T, Potempa J. Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis. J Periodontal Res 1997; 32(1): 120-5.
5. Mealey BL, Rose LF. Diabetes mellitus and inflammatory periodontal diseases. Curr Opin Endocrinol Diabetes Obes 2008; 15(2): 135-41.
6. Beck JD, Offenbacher S, Williams R, Gibbs P, Garcia R. Periodontitis: a risk factor for coronary heart disease? Ann Periodontol 1998; 3(1): 127-41.
7. Detert J, Pischon N, Burmester G, Buttgereit F. The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther 2010; 12(5): 218.
8. Ide M, Papapanou PN. Epidemiology of association between maternal periodontal disease and adverse pregnancy outcomes–systematic review. J Clin Periodontol 2013;4 0(s14).
9. Martinez-Martinez RE, Abud-Mendoza C, Patiño-Marin N, Rizo-Rodríguez JC, Little JW, Loyola-Rodríguez JP. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol 2009; 36(12): 1004-10.
10. Liao F, Li Z, Wang Y, Shi B, Gong Z, Cheng X. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypotheses 2009; 72(6): 732-5.
11. Haraszthy V, Zambon J, Trevisan M, Zeid M, Genco R. Identification of periodontal pathogens in atheromatous plaques. J Periodontol 2000; 71(10): 1554-60.
12. Kurihara N, Inoue Y, Iwai T, Umeda M, Huang Y, Ishikawa I. Detection and localization of periodontopathic bacteria in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 2004; 28(5): 553-8.
13. Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, et al. Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. BMC Gastroenterol 2012; 12(1): 1.
14. Singhrao SK, Harding A, Poole S, Kesavalu L, Crean S. Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer’s disease. Mediators Inflamm 2015; 2015.
15. Boggess KA, Madianos PN, Preisser JS, Moise KJ, Offenbacher S. Chronic maternal and fetal Porphyromonas gingivalis exposure during pregnancy in rabbits. Am J Obstet Gynecol 2005; 192(2): 554-7.
16. Bélanger M, Reyes L, Von Deneen K, Reinhard MK, Progulske-Fox A, Brown MB. Colonization of maternal and fetal tissues by Porphyromonas gingivalis is strain-dependent in a rodent animal model. Am J Obstet Gynecol 2008; 199(1): 86.e1-e7.
17. Fardini Y, Chung P, Dumm R, Joshi N, Han YW. Transmission of diverse oral bacteria to murine placenta: evidence for the oral microbiome as a potential source of intrauterine infection. Infect Immun 2010; 78(4): 1789-96.
18. León R, Silva N, Ovalle A, Chaparro A, Ahumada A, Gajardo M, et al. Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor. J Periodontol 2007; 78(7): 1249-55.
19. Ercan E, Eratalay K, Deren O, Gur D, Ozyuncu O, Altun B, et al. Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight. Acta Odontol Scand 2013; 71(3-4): 553-9.
20. Barak S, Oettinger-Barak O, Machtei EE, Sprecher H, Ohel G. Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. J Periodontol 2007; 78(4): 670-6.
21. Swati P, Thomas B, Vahab SA, Kapaettu S, Kushtagi P. Simultaneous detection of periodontal pathogens in subgingival plaque and placenta of women with hypertension in pregnancy. Arch Gynecol Obstet 2012; 285(3): 613-9.
22. Chaparro A, Blanlot C, Ramirez V, Sanz A, Quintero A, Inostroza C, et al. Porphyromonas gingivalis, Treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case–control study. J Periodontal Res 2013; 48(6): 802-9.
23. Katz J, Chegini N, Shiverick K, Lamont R. Localization of P. gingivalis in preterm delivery placenta. J Dent Res 2009; 88(6): 575-8.
24. Offenbacher S, Jared H, O'reilly P, Wells S, Salvi G, Lawrence H, et al. Potential pathogenic mechanisms of periodontitis-associated pregnancy complications. Ann Periodontol 1998; 3(1): 233-50.
25. Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol 1996; 11(4): 266-73.
26. Kyrklund-Blomberg NB, Granath F, Cnattingius S. Maternal smoking and causes of very preterm birth. Acta Obstet Gynecol Scand 2005; 84(6): 572-7.
27. Moutsopoulos NM, Madianos PN. Low-Grade Inflammation in Chronic Infectious Diseases. Ann N Y Acad Sci 2006; 1088(1): 251-64.
28. Mercer B, Goldenberg R, Das A, Moawad A, Iams J, Meis P, et al. The preterm prediction study: a clinical risk assessment system. Am J Obstet Gynecol 1996;174(6):1885-95.
29. Dole N, Savitz DA, Hertz-Picciotto I, Siega-Riz AM, McMahon MJ, Buekens P. Maternal stress and preterm birth. Am J Epidemiol 2003; 157(1): 14-24.
30. Lilliecreutz C, Larén J, Sydsjö G, Josefsson A. Effect of maternal stress during pregnancy on the risk for preterm birth. BMC Pregnancy Childbirth 2016; 16(1): 1.
31. Dammann O, Leviton A. Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. Pediatr Res 1997; 42(1): 1-8.
32. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000; 342(20): 1500-7.
33. Romero R, Avila C, Brekus CA, Morotti R. The role of systemic and intrauterine infection in preterm parturition. Ann N Y Acad Sci 1991; 622(1): 355-75.
34. Blanc V, O'Valle F, Pozo E, Puertas A, Leon R, Mesa F. Oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients. Oral Dis 2015; 21(7): 905-12.
35. Davenport ES. Preterm low birthweight and the role of oral bacteria. J Oral Microbiol 2010; 2.
2. Vernal R, Díaz-Zúñiga J, Melgar-Rodríguez S, Pujol M, Diaz-Guerra E, Silva A, et al. Activation of RANKL-induced osteoclasts and memory T lymphocytes by Porphyromonas gingivalis is serotype dependant. J Clin Periodontol 2014; 41(5): 451-9.
3. Kato H, Taguchi Y, Tominaga K, Umeda M, Tanaka A. Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells. Arch Oral Biol 2014; 59(2): 167-75.
4. Travis J, Pike R, Imamura T, Potempa J. Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis. J Periodontal Res 1997; 32(1): 120-5.
5. Mealey BL, Rose LF. Diabetes mellitus and inflammatory periodontal diseases. Curr Opin Endocrinol Diabetes Obes 2008; 15(2): 135-41.
6. Beck JD, Offenbacher S, Williams R, Gibbs P, Garcia R. Periodontitis: a risk factor for coronary heart disease? Ann Periodontol 1998; 3(1): 127-41.
7. Detert J, Pischon N, Burmester G, Buttgereit F. The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther 2010; 12(5): 218.
8. Ide M, Papapanou PN. Epidemiology of association between maternal periodontal disease and adverse pregnancy outcomes–systematic review. J Clin Periodontol 2013;4 0(s14).
9. Martinez-Martinez RE, Abud-Mendoza C, Patiño-Marin N, Rizo-Rodríguez JC, Little JW, Loyola-Rodríguez JP. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol 2009; 36(12): 1004-10.
10. Liao F, Li Z, Wang Y, Shi B, Gong Z, Cheng X. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypotheses 2009; 72(6): 732-5.
11. Haraszthy V, Zambon J, Trevisan M, Zeid M, Genco R. Identification of periodontal pathogens in atheromatous plaques. J Periodontol 2000; 71(10): 1554-60.
12. Kurihara N, Inoue Y, Iwai T, Umeda M, Huang Y, Ishikawa I. Detection and localization of periodontopathic bacteria in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 2004; 28(5): 553-8.
13. Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, et al. Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. BMC Gastroenterol 2012; 12(1): 1.
14. Singhrao SK, Harding A, Poole S, Kesavalu L, Crean S. Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer’s disease. Mediators Inflamm 2015; 2015.
15. Boggess KA, Madianos PN, Preisser JS, Moise KJ, Offenbacher S. Chronic maternal and fetal Porphyromonas gingivalis exposure during pregnancy in rabbits. Am J Obstet Gynecol 2005; 192(2): 554-7.
16. Bélanger M, Reyes L, Von Deneen K, Reinhard MK, Progulske-Fox A, Brown MB. Colonization of maternal and fetal tissues by Porphyromonas gingivalis is strain-dependent in a rodent animal model. Am J Obstet Gynecol 2008; 199(1): 86.e1-e7.
17. Fardini Y, Chung P, Dumm R, Joshi N, Han YW. Transmission of diverse oral bacteria to murine placenta: evidence for the oral microbiome as a potential source of intrauterine infection. Infect Immun 2010; 78(4): 1789-96.
18. León R, Silva N, Ovalle A, Chaparro A, Ahumada A, Gajardo M, et al. Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor. J Periodontol 2007; 78(7): 1249-55.
19. Ercan E, Eratalay K, Deren O, Gur D, Ozyuncu O, Altun B, et al. Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight. Acta Odontol Scand 2013; 71(3-4): 553-9.
20. Barak S, Oettinger-Barak O, Machtei EE, Sprecher H, Ohel G. Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. J Periodontol 2007; 78(4): 670-6.
21. Swati P, Thomas B, Vahab SA, Kapaettu S, Kushtagi P. Simultaneous detection of periodontal pathogens in subgingival plaque and placenta of women with hypertension in pregnancy. Arch Gynecol Obstet 2012; 285(3): 613-9.
22. Chaparro A, Blanlot C, Ramirez V, Sanz A, Quintero A, Inostroza C, et al. Porphyromonas gingivalis, Treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case–control study. J Periodontal Res 2013; 48(6): 802-9.
23. Katz J, Chegini N, Shiverick K, Lamont R. Localization of P. gingivalis in preterm delivery placenta. J Dent Res 2009; 88(6): 575-8.
24. Offenbacher S, Jared H, O'reilly P, Wells S, Salvi G, Lawrence H, et al. Potential pathogenic mechanisms of periodontitis-associated pregnancy complications. Ann Periodontol 1998; 3(1): 233-50.
25. Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol 1996; 11(4): 266-73.
26. Kyrklund-Blomberg NB, Granath F, Cnattingius S. Maternal smoking and causes of very preterm birth. Acta Obstet Gynecol Scand 2005; 84(6): 572-7.
27. Moutsopoulos NM, Madianos PN. Low-Grade Inflammation in Chronic Infectious Diseases. Ann N Y Acad Sci 2006; 1088(1): 251-64.
28. Mercer B, Goldenberg R, Das A, Moawad A, Iams J, Meis P, et al. The preterm prediction study: a clinical risk assessment system. Am J Obstet Gynecol 1996;174(6):1885-95.
29. Dole N, Savitz DA, Hertz-Picciotto I, Siega-Riz AM, McMahon MJ, Buekens P. Maternal stress and preterm birth. Am J Epidemiol 2003; 157(1): 14-24.
30. Lilliecreutz C, Larén J, Sydsjö G, Josefsson A. Effect of maternal stress during pregnancy on the risk for preterm birth. BMC Pregnancy Childbirth 2016; 16(1): 1.
31. Dammann O, Leviton A. Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. Pediatr Res 1997; 42(1): 1-8.
32. Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000; 342(20): 1500-7.
33. Romero R, Avila C, Brekus CA, Morotti R. The role of systemic and intrauterine infection in preterm parturition. Ann N Y Acad Sci 1991; 622(1): 355-75.
34. Blanc V, O'Valle F, Pozo E, Puertas A, Leon R, Mesa F. Oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients. Oral Dis 2015; 21(7): 905-12.
35. Davenport ES. Preterm low birthweight and the role of oral bacteria. J Oral Microbiol 2010; 2.
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